慢性精神分裂症患者血清hs-CRP、TC/HDL-C比值与精神症状的关系

摘要

Objective To investigate the relation between serum levels of high sensitivity CRP (hs-CRP ) and total cholesterol/high density lipoprotein cholesterol(TC/HDL-C) with mental symptoms in patients with chronic schizophrenics .Meth-ods Serum hs-CRP ,TC and HDL-C were measured in 65 patients with schizophrenia(schizophrenia group) and contemporaneous 62 individuals undergoing healthy physical examination(healthy control group) .The ratio of TC/HDL-C was calculated ;the Positive and Negative Syndrome Scale(PANSS) was used to assess the mental symptoms of the patients .Results The level of serum hs-CRP in the schizophrenia group was (2 .87 ± 0 .75)mg/L ,which was significantly higher than (0 .96 ± 0 .25)mg/L in the healthy control group;the level of serum TC in the schizophrenia group was (1 .93 ± 0 .51)mmol/L ,which was significant lower than (3 .97 ± 1 .15)mg/L in the healthy control group ;the level of serum HDL-C in the schizophrenia group was (1 .08 ± 0 .33)mmol/L , which was significant lower than (1 .74 ± 0 .42)mg/L in the healthy control group ,the differences were statistically significant (P<0 .05);the ratio value of TC/HDL-C in the schizophrenia group was 1 .78 ± 0 .59 ,which was significantly lower than 2 .28 ± 0 .61 in the healthy control group(P=0 .028) .The correlation analysis showed that serum TC/HDL-C ratio value was negatively correlated with the positive symptoms (r= -0 .34 ,P=0 .004) ,while the serum hs-CRP level was positively correlated with the positive symp-toms(r=0 .31 ,P=0 .010) .Conclusion There is close relationship between inflammation reaction and serum lipid with schizophre-nia .The combined detection of TC/HDL-C and hs-CRP is conducive to predict the occurrence of schizophrenia and can be used as the risk factors of schizophrenia .%目的 探讨慢性精神分裂症患者血清超敏C反应蛋白(hs-CRP)、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)比值与精神症状的关系.方法 检测65例精神分裂症患者(患者组)和62例同期健康体检者(健康对照组)血清hs-CRP、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,并计算TC/HDL-C比值;阳性和阴性症状量表(PANSS)评定患者入组时的精神症状.结果 患者组血清hs-CRP水平[(2.87±0.75)mg/L]显著高于健康对照组[(0.96±0.25)mg/L],患者组血清TC水平[(1.93±0.51)mmol/L]显著低于健康对照组[(3.97±1.15)mg/L],患者组血清HDL-C水平[(1.08±0.33)mmol/L]显著低于健康对照组[(1.74±0.42)mg/L],差异均有统计学意义(P<0.05);患者组血清TC/HDL-C比值(1.78±0.59)显著低于健康对照组的(2.28±0.61)(P=0.028).相关性分析显示,患者组血清TC/HDL-C比值与阳性症状呈负相关(r=-0.34,P=0.004),患者组血清hs-CRP水平与阳性症状呈正相关(r=0.31,P=0.010).结论 血脂和炎性反应与精神分裂症有密切关系,联合hs-CRP、TC/HDL-C比值的检测有利于预测精神分裂症的发生,可以作为精神分裂症的危险因素.