目的：分析托吡酯用于癫痫患者治疗中的价值及对血糖等的影响。方法将该院88例癫痫患者纳入研究，分为2组，托吡酯组（n＝44）患者给予托吡酯治疗，丙戊酸钠组（n＝44）患者给予丙戊酸钠治疗。分别于治疗前及治疗后3、6个月测定2组患者的血糖、总胆固醇、三酰甘油、高密度脂蛋白及低密度脂蛋白水平，观察治疗中的不良反应发生情况。结果治疗后3、6个月，托吡酯组患者体质量及体质量指数均明显低于丙戊酸钠组患者，差异有统计学意义（P＜0．05）。治疗前及治疗后3个月2组患者血糖、总胆固醇、三酰甘油、高密度脂蛋白及低密度脂蛋白水平比较，差异无统计学意义（P＞0．05）。治疗后6个月，托吡酯组患者的血糖、总胆固醇均明显低于丙戊酸钠组患者，且高密度脂蛋白相对更高，差异有统计学意义（P＜0．05）。托吡酯组患者疗效明显优于丙戊酸钠组患者，差异有统计学意义（P＜0．05）。治疗后2组均未出现明显血糖异常及自主神经系统功能异常，但有少量精神及神经系统反应，差异无统计学意义（P＞0．05）。结论托吡酯可明显改善癫痫患者血糖代谢，调节患者血糖，效果良好，安全性高。%Objective To study topiramate used in epilepsy patients in the treatment and its effect on blood glucose .Methods Totally 88 cases of epilepsy patients were included in the study ,and they were randomly divided into two groups ,topiramate group were treated with topiramate ,sodium valproate group were treated with sodium valproate .Blood glucose ,total cholesterol ,three tri‐glyceride ,high density lipoprotein and low density lipoprotein were measured before treatment and 3 and 6 months after treatment , and the adverse reactions were observed in the treatment of two groups .Results After treatment for 3 and 6 months ,body mass and body mass index in topiramate group were significantly lower than sodium valproate group ,the difference was statistically sig‐nificant (P<0 .05) .Before treatment and after treatment for 3 months ,there were no significant difference between the two groups of patients with blood glucose ,total cholesterol ,three acyl glycerin ,high density lipoprotein and low density lipoprotein(P>0 .05) . After treatment for 6 months ,topiramate group of patients with blood glucose and total cholesterol were significantly lower than so‐dium valproate group ,and high density lipoprotein was relatively higher ,the difference was statistically significant (P<0 .05) .The curative effect of topiramate patients was obviously superior to sodium valproate group ,the difference was statistically significant (P<0 .05) .There were no significant abnormal blood glucose and autonomic nervous system dysfunction after treatment ,but there was a little mental and nervous system response ,the difference was not statistically significant (P>0 .05) .Conclusion Topiramate can significantly improve glucose metabolism in patients with epilepsy ,which can regulate blood glucose ,with good effect and high safety .
展开▼
