网织红细胞相关参数在新生儿病理性黄疸检测中的意义

摘要

目的 探讨网织红细胞相关参数在新生儿病理性黄疸中的意义.方法 选取2012年1月至2016年12月于该院诊治的新生儿病理性黄疸439例作为研究对象,其中溶血性黄疸130例,母乳性黄疸96例,感染性黄疸124例,梗阻性黄疸89例;另选取足月健康新生儿100例作为足月健康新生儿组.收集各组临床资料及网织红细胞相关参数,通过数据分析探讨网织红细胞相关参数在新生儿病理性黄疸中的意义.结果 网织红细胞百分比(RET％)在溶血性黄疸组、母乳性黄疸组、感染性黄疸组、梗阻性黄疸组和足月健康新生儿组5个组间差异均有统计学意义(P＜0.01),LSD-t检验结果显示,溶血性黄疸组和梗阻性黄疸组分别与其他4组比较,差异均有统计学差异(P＜0.01);母乳性黄疸组、感染性黄疸组和足月健康新生儿组两两比较差异均无统计学意义(P＞0.05).网织红细胞绝对值(RET #)在5组中差异有统计学意义(P＜0.01),按α＝0.05检验水准,除溶血性黄疸组与其他4组差异有统计学意义外,其他4组两两比较差异均无统计学意义(P＞0.05).5组中高荧光网织红细胞比例(H-TC％)差异有统计学意义(P＜0.01),经LSD-t检验显示,溶血性黄疸组、感染性黄疸组分别与其他4组比较,差异均有统计学意义(P＜0.01),而母乳性黄疸组、梗阻性黄疸组和足月健康新生儿组两两比较差异无统计学意义(P＞0.05).低核酸网织红细胞比例在5组表现出与 H-TC％相似的情况,即溶血性黄疸组、感染性黄疸组分别与其他4组比较,差异均有统计学意义(P＜0.05),而母乳性黄疸组、梗阻性黄疸组和足月健康新生儿组两两比较差异均无统计学意义(P＞0.05).中核酸网织红细胞比例则表现出与RET #相似的情况.结论 网织红细胞相关参数检测对新生儿病理性黄疸的诊断有一定临床意义.%Objective To explore the significance of reticulocyte related parameters in the detection of neo-natal pathological jaundice.Methods A total of 439 cases of neonatal pathological jaundice who treated in hos-pital from January 2012 to December 2016 were enrolled in the study,including 130 cases of hemolytic jaun-dice,96 cases of breast milk jaundice,124 cases of infectious jaundice,89 cases of obstructive jaundice and an-other 100 cases of normal full-term newborns were taken as the full term healthy newborn group.the clinical data were collected,and the related parameters of reticulocyte were determinated.The significance of neonatal pathological jaundice and the correlative parameters of reticulocyte was explored through the analysis of the data.Results The percentage of reticulocyte percentage(RET％)was significantly different between hemo-lytic jaundice group,breast milk jaundice group,infectious jaundice group,obstructive jaundice group,and full-term normal neonatal group(P＜0.01).LSD-t test results showed that the hemolytic jaundice group and the obstructive jaundice group had statistically significant difference compared with the other four groups(P＜0.01).Compare in pairs,there was no significant difference between the groups in the breast milk jaundice group the infectious jaundice group and the full-term normal neonatal group(P＞0.05).The absolute value of reticulocyte(RET#)in the five groups was statistically significant(P＜0.01).According to α＝0.05 level,there was no significant difference between the other four groups in pair comparison except there was a signifi-cant difference between hemolytic jaundice group and the other four groups.The ratio of H-TC％in the 5 groups was statistically significant(P＜0.01),and LSD-t test showed that the differences of hemolytic jaun-dice group,infectious jaundice group and other 4 groups were statistically significant(P＜ 0.01),however there was no significant difference in breast milk jaundice group,obstructive jaundice group and full-term healthy newborn group in pair comparison(P＞0.05).The ratio of RNA in the 5 groups was similar to that in the 5 groups,namely,the hemolytic jaundice group,the infectious jaundice group and the other 4 groups were statistically significant,but there was no statistical significance between the breast milk jaundice group,the obstructive jaundice group and the full term healthy newborn group in pair comparison.The proportion of nu-cleic acid reticulocyte showed similar condition to that of RET #.Conclusion Reticulocyte related parameters have certain clinical significance in the detection of neonatal pathological jaundice.