血清降钙素原和白细胞介素-6在诊断成人急性阑尾炎穿孔中的价值

摘要

目的 探讨急性阑尾炎患者血清中降钙素原(PCT)与白细胞介素-6(IL-6)水平对急性阑尾炎穿孔的诊断价值.方法 回顾性分析该院2015年1月至2016年1月确诊的266例急性阑尾炎成年患者入院时血清PCT与IL-6水平,依据病理报告将所有患者分为急性单纯性阑尾炎组与急性阑尾炎穿孔组,分析两组之间血清PCT与IL-6水平差异,采用ROC曲线计算血清PCT与IL-6的截断值;追踪2016年2-7月的73例新入院急性阑尾炎患者临床资料,验证血清PCT与IL-6截断值对急性阑尾炎穿孔的诊断效能.结果 血清PCT＞2.61 ng/mL,IL-6＞27 pg/mL时提示急性阑尾炎穿孔,并且血清PCT与IL-6联合检测时诊断效能明显提高.结论 血清PCT与IL-6的水平对诊断急性阑尾炎穿孔具有重要价值.%Objective To analyze and discuss the predictive value of serum level of calcitonin and interleukin-6 in patients with acute appendicitis perforation.Methods A total of 266 cases diagnosed for adult patients admitted to our hospital with acute appendicitis from January 2015 to January 2016 were selected,the serum calcitonin factor and interleukin-6 levels were retrospectively analyzed.All patients were divided into acute appendicitis group and acute appendicitis perforation group according to the pathological report.The differences of serum PCT and interleukin-6 levels between the two groups were analyzed,and the cut-off values of serum PCT and interleukin-6 were calculated by ROC curve.The clinical data of 73 patients with acute appendicitis admitted to the hospital from February 2016 to July were analyzed in order to verify the effectiveness of the truncated value of serum calcitonin and interleukin-6 in acute appendicitis perforation.Results The level of serum calcitonin was higher than 2.61 ng/mL,and the interleukin-6 was higher than 27 pg/mL indicated acute appendicitis perthe diagnostic efficiency of serum PCT and IL-6 was improved significantly.Conclusion The level of serum calcitonin and interleukin-6 can assist in the diagnosis of perforated appendix.