Objective To investigate the relationship between the levels of inflammatory and immunological indexes and renal diseases in patients with diabetes mellitus .Methods 106 patients with diabetes were select-ed in Huai′an First People′s Hospital Affiliated to Nanjing Medical University from July 2014 to August 2016 and were divided into diabetic group (C group with 55 cases) and diabetic nephropathy group(D group with 51 cases) .Diabetic nephropathy group were divided into better prognosis group (group E) and poor prognosis group(group F) .The expression of inflammatory and immunological indexes in each group were observed .Re-sults The levels of LDL-C ,TG ,HbA1c and TC in D groups were significantly higher than those in C group (P<0 .05) and the levels of TG ,HbA1c ,TC and LDL-C in F group were significantly higher than those in E group(P<0 .05) .The expression of inflammatory factors including IL-6 ,IL-1 ,TNF-αand hs-CRP in C group were significantly lower than those in D group (P<0 .05) and the levels of IL-6 ,IL-1 ,TNF-αand hs-CRP in F group were significantly higher than those in E group (P<0 .05) .The expression level of IgG were no differ-ence between C group and D group(P>0 .05) and the expression levels of IgA and IgM in C group were sig-nificantly lower than those in group D (P<0 .05) .The expression levels of CD4+ ,CD8+ ,CD3+ T cells and B cells were no difference between C group and D group (P>0 .05) and the expression levels of NK cells were significantly higher than that of D group (P< 0 .05) .The expression of IgG were no difference between E group and F group(P>0 .05) and the expression levels of IgA and IgM in E group were significantly lower than those in F group(P<0 .05) .The expression levels of CD3+ T cells and B cells were no difference between E group and F group(P>0 .05) and the expression of CD4+ T cells and NK cells were significantly higher than that of F group ( P< 0 .05) and the expression level of CD8+ T cells was significantly lower than that of F group(P<0 .05) .Conclusion The levels of immunological index including IgA ,IgM ,NK and inflammatory factors including IL-6 ,IL-1 ,TNF-α,hs-CRP are highly expressed in diabetic patients with nephropathy .The high expression of inflammatory factors and immunological indexes may be closely related to diabetic patients combined with kidney disease .%目的 研究糖尿病患者炎症及免疫学指标水平与其肾脏病变的相关性.方法 选取淮安第一医院在2014年7月至2016年8月收治的106例糖尿病患者.按照是否发生糖尿病肾病将患者分成糖尿病组(C组,55例)与糖尿病肾病组(D组,51例),糖尿病肾病组又分为预后较好组(E组)与预后不良组(F组).观察各组患者血脂、炎症指标以及免疫学指标的表达情况.结果 D组患者三酰甘油(TG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)以及低密度脂蛋白胆固醇(LDL-C)表达水平明显高于C组(P<0.05);F组患者TG、HbA1c、TC以及LDL-C表达水平明显高于E组(P<0.05).炎症因子中,D组患者IL-6、IL-1、TNF-α、超敏C反应蛋白(hs-CRP)表达情况明显高于C组(P<0.05);F组患者IL-6、IL-1、TNF-α、hs-CRP表达情况明显高于E组(P<0.05).在体液免疫指标中,C组患者IgG表达水平与D组比较差异无统计学意义(P>0.05),而IgA、IgM的表达水平明显低于D组(P<0.05);E组患者IgG表达情况与F组比较差异无统计学意义(P>0.05),而IgA与IgM表达情况明显低于F组(P<0.05).在细胞免疫指标中,C组患者CD3+、CD4+、CD8+T细胞以及B细胞表达情况与D组比较差异无统计学意义(P>0.05),而NK细胞水平明显高于D组(P<0.05);E组CD3+T细胞、B细胞水平与F组比较差异无统计学意义(P>0.05),而CD4+T细胞、NK细胞的表达水平明显高于F组(P<0.05),CD8+T细胞表达水平明显低于F组(P<0.05).结论 糖尿病肾病患者中免疫学指标IgA、IgM、NK细胞与炎症因子IL-6、IL-1、TNF-α、hs-CRP高度表达,可能与患者发生肾脏病变密切相关.
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