老年烧伤患者康复期抑郁评分与血清BDNF、MIF、NPY的相关性分析

摘要

目的 研究烧伤后康复期老年患者抑郁评分与血清脑源性神经营养因子(brain derived neurotrophic factors,BDNF)、巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)、神经肽(neuropeptide Y,NPY)的关系.方法 选取2015年2月至2016年8月我院收治的56例烧伤康复期老年患者为观察组,另选同期56例健康体检老年人为对照组.对比两组血清BDNF、MIF、NPY水平,并分析其与抑郁程度的相关性.结果 观察组血清BDNF水平显著低于对照组,而MIF、NPY水平均显著高于对照组;随着抑郁程度的逐渐加重,患者血清中BDNF水平逐渐降低,而MIF、NPY水平逐渐升高.经由相关性分析,患者抑郁评分与血清BDNF呈显著负相关(R=-0.452,P=0.004),而与MIF、NPY均呈显著正相关(R=0.563,P=0.000;R=0.587,P=0.000).结论 烧伤后康复期老年患者抑郁评分与血清BDNF呈显著负相关,与MIF、NPY呈显著正相关,上述三项血清指标可作为诊断及判断患者抑郁程度的参考指标.%Objective To study the relatioinship between depression score and levels of serum BDNF, MIF, and neuropeptide Y (NPY) during postburn rehabilitation period in elderly patients.Methods From February 2015 to August 2016, 56 cases elderly patients with burn treated in our hospital after rehabilitation were selected as the observation group, and during the same period, 56 cases of healthy old people as control group.We compared two groups of serum BDNF, MIF, NPY levels and depression degree and did the correlation analysis.Results The observation group′s serum BDNF level was significantly lower than that of the control group.MIF, NPY levels were significantly higher than those of the control group.With depression aggravated gradually, the serum BDNF levels decreased gradually, and MIF, NPY levels increased gradually.The differences were significant (P<0.05).Through the correlation analysis, patients depression score and serum BDNF was significantly negative correlated (R=-0.452, P=0.004), and depression score and MIF, NPY was positively related (R=0.563, P=0.000;R=0.587, P=0.000).Conclusion There was a significant negative correlation between depression score and serum BDNF, a significant positive correlation between depression score and MIF, NPY in the elderly patients with post burn rehabilitation.The above three indexes can be used as the diagnosis and clinical indicators of the degree of depression.