原发性肝细胞癌组织中环氧化酶-2及E-钙黏蛋白的表达

摘要

Aim: To investigate the expressions of cyclooxygenase-2( COX-2) and E-cadherin in hepatocellular carcino-ma( HCC) tissue. Methods:The expressions of COX-2 and E-cadherin in 64 cases of HCC and 12 cases of normal liver tissue were detected by immunohistochemistry. Results: The expression rate of COX-2 in HCC tissue was higher than that in normal liver tissue( 75.0% vs 28. 3% ,X2 = 16.805 ,P < 0. 001 ) . The expression rate of E-cadherin in HCC tissue was lower than that in normal liver tissue(51. 6%νs83.3% X2 =4. 152,P =0.042). The expression of COX-2 in HCC tissue was related with clinical stage(X2 =9.069 ,P =0. 011) . The expression of E-cadherin in HCC tissue was related with tissue differentiation X2 = 7.635,P=0.022)as well as clinical stage(X2 =6. 786,P =0. 034) . The expression of COX-2 and E-cadherin was negatively associated in HCC tissue (rp =0.324,P =0.006). Conclusion; The high expression of COX-2 and low expression of E-cadherin in HCC tissue may play roles in the occurrence and development of HCC tissue, and the two markers are probably to become indicators predicting the invasive characteristic of HCC.%目的：检测原发性肝细胞癌(HCC)组织中环氧化酶-2(COX-2)及E-钙黏蛋白(E-cadherin)的表达。方法：采用免疫组化法检测64例HCC组织及12例正常肝组织中COX-2及E-cadherin的表达，并分析二者在HCC组织中的关联性及与临床病理特征的关系。结果：HCC组织中COX-2的表达高于正常肝组织(75.0％vs8.3％，x2=16.805，P＜0.001)。HCC组织中E-cadherin的表达低于正常肝组织(51.6％vs83.3％，x2=4.152,P=0.042)。HCC组织中COX-2的表达与临床分期有关(x2=9.069，P=0.011)，E-cadherin的表达与组织分化程度(X2=7.635，P=0.022)及临床分期(X2=6.786，P=0.034)均有关。HCC组织中COX-2及E-cadherin蛋白的表达呈负关联(rp=0.324，P=0.006)。结论：HCC组织中COX-2蛋白高表达及E-cadherin蛋白低表达可能在HCC的发生、发展中发挥一定作用，二者联合检测可能用于预测HCC的侵袭性。