Aim: To investigate the predictability of cyclooxygenase-2 ( COX-2) and Survivin on sensitivity of Neo-adjuvant chemotherapy in gastric carcinoma. Methods: 96 gastric carcinoma patients were divided into the experimental group with 42 cases treated by both Neo-adjuvant chemotherapy of FOLFOX 4 and surgery and 54 cases with routine surgery as control. Surgery would be performed three weeks after the chemotherapy on the experimental group. Define the sensitive and insensitive cases by the comparative efficacy before and after surgery. Record the expression of COX-2 and Survivin protein in gastric carcinoma tissues before and after surgery by SP. Results: The differences of COX-2 expressions before and after treatment showed obvious differences(t = 3. 452,P = 0. 002) , while an ascending tendency of the Survivin expressions(t = 3.751 ,P =0. 017) between the experimental and control group. Survivin expressions shown significant difference between sensitive and insensitive group before and after Neo-adjuvant chemotherapy(t = 2. 673 ,P =0.027). It shown low-level expression of Survivin and significant difference in pre-Neoadjuvant chemotherapy of sensitive group. Conclusion: Patients with low-level Survivin expression was more sensitive to Neo-adjuvant chemotherapy. The expression of Survivin could be a sensitive indicator in predicting the efficacy of Neo-adjuvant chemotherapy in gastric carcinoma.%目的:检测多囊卵巢综合征(PCOS)患者子宫内膜组织中同源框基因(HOX)A10的表达.方法:采集20例已婚PCOS患者和26例已婚正常育龄妇女子宫内膜组织标本,HE染色判定内膜分期,采用免疫组化SP法检测不同患者子宫内膜HOXA10的表达.结果:PCOS患者子宫内膜间质反应不良和PCOS分泌中期组的子宫内膜分泌反应欠佳的发生率均高于对照者,差异有统计学意义(P=0.022和0.004).4组间子宫内膜组织HOXA10蛋白的表达比较,差异有统计学意义(F=4.732,P<0.001).其在PCOS和对照分泌中期子宫内膜的表达水平均高于相应的增生期组(P<0.05);在PCOS增生期和分泌中期组子宫内膜的表达水平均低于相应的对照组(P<0.05).结论:PCOS患者内膜HOXAIO的低表达可能参与了其内膜容受性下降的发生、发展过程.
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