子宫内膜异位症患者血清和腹腔液中CA125和抗转铁蛋白抗体水平测定

摘要

目的:探讨CA125和抗转铁蛋白抗体(TFAb)在子宫内膜异位症(EMT)患者血清和腹腔液中的表达水平及其诊断价值.方法:采用ELISA法检测52例EMT(Ⅰ、Ⅱ期25例,Ⅲ、Ⅳ期27例)患者及40例对照血清和腹腔液中CA125和TFAb的水平.结果:3组血清和腹腔液中CA125的水平差异有统计学意义(F=21.997和45.551,P＜0.001);EMTⅢ、Ⅳ期患者血清和腹腔液中CA125水平高于Ⅰ、Ⅱ期患者(P＜0.05).3组血清、腹腔液中CA125和TFAb阳性率的比较,差异有统计学意义(χ2=18.945、40.926和59.916、59.919,P＜0.05).采用CA125和TFAb串联试验对EMT诊断的特异性可达到100.0%,CA125和TFAb并联试验中腹腔液对EMT诊断的灵敏性为94.2%.结论:CA125和TFAb均有助于EMT的诊断,联合测定血清或腹腔液中CA125和TFAb可提高诊断的准确性.%Aim: To investigate the expressions and diagnostic values of CA125 and antibody to transferrin ( TFAb) in serum and peritoneal fluid from patients with endometriosis ( EMT). Methods :CA125 and TFAb in serum and peritoneal fluid from 52 patients with EMT (25 patients with stage Ⅰ,Ⅱ and 27 patients with stage Ⅲ , Ⅳ ) and 40 controls were measured by ELISA. Results:The levels of CA125 in serum and peritoneal fluid from patients with EMT were higher than those in the control group (x2 =21.997 and 45. 551 ,P <0. 001 ). The levels of CA125 in serum and peritoneal fluid increased with stage-level rise (P<0.05). The positive rates of CA125 and TFAb in serum and peritoneal fluid among the groups were different significantly (x2 =18.945,40.926 and 59. 916,59. 919, P < 0. 05 ). The sensitivity and specificity were up to 94.2% and 100.0% respectively when the CA125 combined with TFAb were used to diagnose EMT. Conclusion: CA125 and TFAb levels in serum and peritoneal fluid is useful for EMT diagnosis, and combined determination of CA125 and TFAb in serum or peritoneal fluid can improve the diagnostic accuracy.