姜黄素对多囊卵巢综合征大鼠代谢紊乱的影响

摘要

To explore the effects of curcumin (Cur) on rats with polycystic ovary syndrome (PCOS).Meth-ods:30 female SD rats were randomly divided into normal group , model group, Cur (200 mg· kg-1 ) group, and 10 in each group .The model of PCOS was set up by intragastricly administrating with letrozole .Body mass , bilateral ovarian weight, fasting blood glucose (FBG) were determined, luteinizing hormone (LH), testosterone (T), insulin (FINS) in serum were assayed with radioimmunoassay method , adiponectin ( APN) in serum was detected with enzyme-linked immu-nosorbent assay method and homeostasis model assessment of insulin resistance ( HOMA-IR) was calculated .Results:The body weight, bilateral ovarian mass, LH, T, FBG, FINS, HOMA-IR and APN had significant differences (F=6.530, 6.755,20.379,37.488,8.456,12.851,14.854 and 36.371,P<0.05);APN level in Cur group significantly increased as compared with the model group,and the other indexes decreased (P<0.05).Conclusion:Curcumin can decrease andro-gen level and ovarian weight of PCOS rats , which may be related with its reducing weight , relieving insulin resistance and regulating adiponectin .%目的：探讨姜黄素（Cur）对多囊卵巢综合征（PCOS）大鼠代谢紊乱的影响。方法：30只雌性SD大鼠随机分为正常组、模型组和Cur组，每组10只。模型组和Cur组通过灌胃来曲唑建立PCOS模型。 Cur组大鼠每日灌胃Cur（200 mg/kg）0．5 mL，模型组和正常组大鼠灌胃等体积的生理盐水，连续14 d 。测定大鼠体重、双侧卵巢质量、空腹血糖（FBG），放射免疫法测定血清黄体生成素（LH）、睾酮（T）、空腹胰岛素（FINS），酶联免疫法测定血清脂联素（ APN），计算稳态模型胰岛素抵抗（ HOMA-IR）。结果：3组大鼠体重、双侧卵巢质量、LH、T、FBG、FINS、HO-MA-IR和APN比较差异有统计学意义（ F＝6．530、6．755、20．379、37．488、8．456、12．851、14．854和36．371，P＜0．05）；Cur组大鼠血清APN水平较模型组上升，其他指标较模型组降低（P＜0．05）。结论：Cur能够降低PCOS大鼠雄激素水平及卵巢质量，可能与其可减轻大鼠体重、缓解胰岛素抵抗、调节脂联素水平有关。