Aim:To investigate the effects of xylometazoline hydrochloride combined with nasal corticosteroids in the treatment of allergic rhinitis.Methods:A total of 60 SD rats were randomly allocated into 3 groups, 20 rats in each group. Using OVA +Al( OH) 3 to establish rat model of allergic rhinitis .Group B was treated with momestasone furoate , group C was treated with xylometazoline hydrochloride plus momestasone furoate , group A was treated with normal saline for 1 week. The eosinophils in nasal mucosa were observed using HE staining .Using immunohistochemistry ( SP method ) to detect ICAM-1 and IL-12 expression levels of the three groups .Results:Compared with group A , the eosinophils in group B and C were much fewer;compared with group B, it was much fewer in group C(F=3 001.500,P<0.001).The expression level of ICAM-1 in nasal mucosa of group A was higher than those in group B and C ,and that in group C was the lowest ( F=4 458.820,P<0.001);the expression level of IL-12 in nasal mucosa of group A was lower than those in group B and C,and that in group C was the highest (F=6 640.770,P<0.001).Conclusion:It is much better to joint xylometazoline hydrochloride and mometasone furoate to relieve allergic rhinitis symptoms than the simple application of nasal corticoste -roid.%目的：探讨盐酸赛洛唑啉联合鼻用糖皮质激素治疗变应性鼻炎（ AR）的疗效。方法：60只健康SD大鼠随机分成A、B、C 3组，每组20只。以卵清白蛋白＋Al（OH）3建立大鼠AR模型后， B组用糠酸莫米松治疗，C组用盐酸赛洛唑啉联合糠酸莫米松治疗，A组以生理盐水代替，共治疗1周。采用HE染色方法观察3组大鼠鼻黏膜组织中嗜酸性粒细胞（EOS）浸润情况；用免疫组化SP法检测大鼠鼻黏膜组织中细胞间黏附分子-1（ICAM-1）、白细胞介素-12（IL-12）的表达水平。结果：与A组比较，B、C两组大鼠鼻黏膜组织中EOS浸润较少，C组较B组更少（F＝3001．500，P＜0．001）；A组鼻黏膜组织中ICAM-1的表达量明显高于B、C组（P＜0．05），其中C组ICAM-1表达量极少（F＝4458．820，P＜0．001）；A组鼻黏膜组织中 IL-12的表达量极少，C 组IL-12表达量最高（ F＝6640．770，P＜0．001）。结论：盐酸赛洛唑啉联合鼻用糖皮质激素治疗可有效降低AR的鼻黏膜炎症反应，其疗效优于单纯运用鼻用糖皮质激素。
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