糖尿病合并非酒精性脂肪肝的危险因素分析

摘要

Aim: To investigate the risk factors of type 2 diabetes mellitus with non-alcoholic fatty liver disease ( NAFLD) .Methods:A total of 261 cases of type 2 mellitus diabetes were collected and allocated into 2 groups according to with or without NAFLD .The risk factors of type 2 mellitus diabetes with NAFLD were analyzed by using logistic regres-sion analysis.Results:The analysis of univariate factor showed that age ,BMI,HBA1C,FPG,TG had statistical significance between the 2 groups(χ2 =7.266,66.897,8.911,9.348,30.161,P<0.05).Logistic regression analysis demonstrated that obesity and increased TG are dangerous factors of type 2 diabetes mellitus with NAFLD[OR(95%CI) =4.503 (2.930-6.919),1.563(1.154-2.117)].Conclusion:Obesity and high level of TG are dangerous factor of type 2 dia-betes mellitus with NAFLD .%目的：探讨2型糖尿病合并非酒精性脂肪肝（ NAFLD）的危险因素。方法：回顾性分析104例2型糖尿病合并NAFLD患者和157例未合并NAFLD糖尿病患者性别、年龄、糖尿病家族史、高血压病史、吸烟史、体重指数（ BMI）、血尿酸、谷丙转氨酶、谷草转氨酶、总胆固醇（ TC）、甘油三酯（ TG）、高密度脂蛋白（ HDL）、低密度脂蛋白（LDL）、超敏C反应蛋白、血浆凝血酶原时间（PT）、糖化血红蛋白（HBA1C）、空腹血糖（FPG）的差异。非条件logis-tic回归模型进行2型糖尿病合并NAFLD的危险因素分析。结果：2组年龄、BMI、HBA1C、FPG、TG差异有统计学意义（χ2＝7．266、66．897、8．911、9．348、30．161，P＜0．05）；Logistic回归模型分析结果显示肥胖、高TG是2型糖尿病合并NAFLD的危险因素[OR（95％CI）＝4．503（2．930～6．919），1．563（1．154～2．117）]。结论：肥胖和高TG是2型糖尿病合并NAFLD的危险因素。