母乳喂养与中国0～6岁儿童肥胖发生风险关系的 meta分析

摘要

Aim:To assess the association between breastfeeding and the risk of obesity of 0-6 years old Chinese children.Methods:We searched for articles with keywords such as breastfeeding ,children,childhood,obesity,China,Chi-nese,etc through CNKI, Wanfang Data, PubMed and Web of Science from 1996 to July 2015.Meta-analysis was performed by the software of STATA 11.0.Results:According to the inclusion criteria , thirteen articles including 49 561 children were selected.Overall analysis showed that , breastfeeding could significantly decrease the risk of obesity ( OR=0.667, 95%CI=0.588-0.756,P<0.001), compared with the formula feeding group .Moreover, we found the similar effect in the subgroup analysis by the variables of age , sample size, and age matched, way of contrast (P<0.05), meanwhile breastfeeding time≥6 months could also statistically decrease the risk of obesity of Chinese children ( OR =0.744, 95%CI=0.600-0.923,P=0.007), compared with breastfeeding time <6 months.Conclusion:Meta-analysis suggests that breastfeeding could decrease the risk of obesity in 0-6 years old Chinese children , especially for the children breastfed for more than 6 months.%目的：综合评价母乳喂养与中国0～6岁儿童肥胖发生风险的关系。方法：在中国知网、万方数据库中检索关键词为“母乳喂养”“儿童”“肥胖”的文献，在PubMed和Web of Science 数据库中检索关键词为“breastfeed-ing”“children”“childhood”“obesity”“China”“Chinese”的文献，检索年限为1996年至2015年7月。利用STATA 11．0进行meta分析。结果：共纳入13篇文献，计49561例。总体分析显示，与人工喂养相比较，母乳喂养可降低中国儿童肥胖的发生风险（OR＝0．667，95％CI＝0．588～0．756，P＜0．001）。对年龄、样本量大小、年龄是否匹配以及对比方式进行亚组分析后，同样发现母乳喂养具有降低中国0～6岁儿童肥胖发生风险的作用（P＜0．05）；母乳喂养持续时间≥6个月与＜6个月相比较，可降低中国0～6岁儿童肥胖的发生风险（OR＝0．744，95％CI＝0．600～0．923，P＝0．007）。结论：Meta分析提示与人工喂养相比较，母乳喂养可降低中国0～6岁儿童肥胖的发生风险，且母乳喂养持续时间超过6个月效果更为显著。