研究了以CuCl2/Al2 O3作为金属铜催化剂高效催化氮杂环与卤代芳烃的N-芳基化反应制备N-芳基杂环化合物.实验结果表明:在无有机配体存在下CuCl2/Al2O3催化剂具有良好的催化活性和重复使用性.以咪唑与碘苯的反应作为模板反应优化反应条件,考察了反应物配比、催化剂种类、碱的种类、溶剂的选择、反应温度以及反应时间等因素对反应收率的影响,确定了最佳反应条件,在此条件下制备N-苯基咪唑的收率达99％.而且,所选择的催化反应体系可应用于合成一系列N-芳基杂环化合物.%An efficient method for N-arylation of nitrogen-containing heterocycles with aryl halides has been developed using CUC12/Al2O3 as an efficient catalyst to prepare a variety of N-arylheterocycles. The experimental results showed that the CuCl2/Al2O3 catalyst has good catalytic activity and can be reused without any added organic ligand. The coupling reaction of iodobenzene with imidazole was used as the model reaction to optimize the reaction conditions, and the influences of molar ratio of reactants, catalyst, base, solvent, temperature and time were investigated. Under the selected reaction conditions, the yield for the preparation of N-phenyl imidazole is 99%. And, the selected catalytic reaction system can be applied in synthesis of a variety of N-arylheterocycles.
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