DDQ氧化法合成3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸酯类化合物

摘要

A series of 3 bromo-1-(3-chloro-2-pyridinyl)-1H-Pyrazole-5-carboxylic acid esters were synthesized viaoxidative dehydrogenation of 3-bromo-1-(3--chloro-2-pyridinyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid esters with DDQ as oxidant,all products were characterized by 1 H NMR 13C NMR and HRMS.This method has the advantages of simple operations,high yields and wide range of application.%以DDQ为氧化剂,对3-溴-1-(3-氯-2-吡啶基)-4,5-二氢-1H-吡唑-5-甲酸酯类化合物进行氧化研究,合成了一系列3-溴-L(3-氯-2-吡啶基)-1H-吡唑-5-甲酸酯类化合物,其结构经氢谱、碳谱和高分辨质谱分析确证,该方法具有操作简便、产率高、适用范围广等优点.