A new methodology based on the results of wind tunnel tests was proposed in order to obtain the wind-induced responses and equivalent static wind loads (ESWLs) of a high-rise building which has complicated shape and is under the aerodynamic interference of other buildings. The resultant forces on layers of the high-rise building were calculated based on the wind pressures measured simultaneously from wind tunnel tests. Based on the simplified layer model, a methodology to obtain the wind-induced responses and ESWLs accounting for different responses was developed in the frequency domain. Then the developed methodology was applied to a high-rise building to show how it works. Results show that the displacements of the building are contributed mainly by the first vibrating mode, whereas the accelerations are contributed by first several vibrating modes. The displacements and accelerations calculated in the frequency domain match well with those calculated in the time domain. Three ESWLs accounting for the displacement on the top of the building, the base shear and the base moment are almost the same for this building. The accumulated value of ESWLs can be used to determine the most unfavorable wind direction.%针对复杂体型和有气动干扰情况下高层建筑的风致响应和设计风荷载问题,提出一种基于风洞试验的计算方法,利用同步测压的风洞试验数据获得高层建筑的风压测层合力,基于简化层模型,在频域内给出该高层建筑风致响应和对应于各种响应等效风荷载的计算方法,并将该方法应用于某高层实例.分析表明:位移响应以第1阶模态贡献为主,加速度响应的前几阶模态均有贡献；采用频域和时域方法获得的位移和加速度响应吻合较好；本实例中基于顶部位移、底部剪力和底部弯矩的等效风荷载结果非常接近；等效风荷载的累加值可用来判断最不利风向角.
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