2型糖尿病中医证型与自身免疫性甲状腺疾病的关系研究

摘要

[目的]探讨2型糖尿病（type 2 diabetes mel itus, T2DM）中医证型与自身免疫性甲状腺疾病的关系，指导T2DM患者筛查甲状腺自身抗体。[方法]选取T2DM阴虚热盛型、湿热困脾型、气阴两虚型、血瘀脉络型及阴阳两虚型患者各30例，对照组健康人30例，测定甲状腺功能及抗体，统计分析中医各证型与甲状腺功能及抗体间的关系。[结果]T2DM甲状腺功能减退患病率高于对照组，阴阳两虚型患者甲状腺功能减退患病率高于其余4型，阴虚热盛型患者TPOAb阳性率高于其余4型，差别均有统计学意义(P<0.05)。[结论]T2DM尤其是阴虚热盛型患者筛查甲状腺自身抗体对T2DM合并自身免疫性甲状腺疾病的早期诊断具有重要意义，且TPOAb检查意义大于TGAb。%[Objective] To study the relationship between type 2 Diabetes(T2DM) in different TCM syndromes and autoimmune thyroid disease(AITD), guide autoimmune thyroid antibodies screening. [Methods] Select 30 cases for every syndrome including yin deficiency and excess heat syndrome ,damp heat syndrome, qi and yin deficiency syndrome,deficiency of yin and yang syndrome and stagnated blood syndrome. 30 cases of healthy people were selected as the normal control group(NCG). Thyroid function and autoimmune thyroid antibodies were measured and the relationship between TCM syndrome and thyroid function and autoimmune thyroid antibodies were analysed. [Results] The prevalence of hypothyroidism of T2DM group was higher than that of NCG, the prevalence of hypothyroidism of deficiency of yin and yang syndrome was higher than other four syndromes, the positive rates of TPOAb of yin deficiency and excess heat syndrome were higher than other syndromes ,with a significant difference. [Conclusion] Examining autoimmune thyroid antibodies of T2DM especial y of yin deficiency and excessive heat syndrome has great importance to early diagnosis and treatment of T2DM with AITD.