连续发酵生产青霉素的工艺设计

摘要

Penicillin is one kind of most common and low toxic β-lactam antibiotic, mainly attained by the fermentation fluid. In our country, it is often produced by fedbatch fermentation, which is timeconsuming, with characteristics such as high costs, laborintensive, complicated process, unstable quality, and can not satisfy the need of modern industrialization. Ac cording to the analysis on the existing process, this article designed a novel process of continuous fermentation for penicillin production.%青霉素是常见的β－内酰胺类抗生素，对人体毒性很低，由发酵液提取获得。在我国一般采用分批发酵法来生产青霉素，此法耗时长、设备昂贵、人工成本高、流程复杂、产品质控难，难以满足现代工业的发展需求。本文通过对现有生产工艺的探讨，对其进行改进，为青霉素生产工业设计了一套崭新的连续发酵工艺。