Objective To investigate the expression of CD44 and nm23 and their relations to lymphnode metastasis in rnbreast invasive ductal carcinoma. Methods The expression of CD44 and nm23 in 32 speciments of breast invasive ductal carrncinoma tissues were detected by S-P immunohistochemistry method. Results The positive expression rate of CD44 and nm23 rnin the group with lymphatic metastasis was 66. 7％ and 26. 7％ resperctively;The positive expression rate of CD44 and nm23 rnin the group without lymphatic metastasis was 23. 5％ and 70. 6％ resperctively. Compared with the group without lymphatic rnmetastasis, the expression of CD44 increased, but the expression of nm23 decreased, there was statistical significance ( P ＜rn0. 05 ) . There was no obvious eorrelation between CD44 and nm23 ( r = - 0. 210 , P ＞ 0. 05 ) . Conclusion There is direct corrnrelation between lymphatic metastasis and the expression of CD44, and there is negative correlation between lymphatic metastarnsis and the expression of nm23. There is no obvious correlation between CD44 and nm23.%目的 探讨CD44和nm23在乳腺浸润性导管癌中的表达及其与淋巴结转移的关系.方法 用免疫组织化学S-P法检测32例乳腺癌标本中CD44和nm23的表达.结果 有淋巴结转移者中CD44和nm23的阳件率分别为66.7%和26.7%,无淋巴结转移者CD44和nm23的阳性率分别为23.5%和70.6%,有淋巴结转移的乳腺癌组织中CD44的阳性表达率明显高于无淋巴结转移的乳腺癌组织,nm23的阳性表达率则明显低于无淋巴结转移的乳腺癌组织,差别均具有统计学意义(P<0.05);乳腺癌组织中CD44与nm23的表达无明显相关性(r=-0.210,P>0.05).结论 乳腺浸润性导管癌淋巴结转移同CD44的表达呈正相关,与nm23的表达呈负相关;CD44和nm23之间未发现明显相关性.
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