Objective To research the relevance between iodine,selenium nutrition status and thyroid carci-noma in patients with thyroid carcinoma in Urumqi.Methods 140 patients with thyroid carcinoma and 147 patients with benign thyroid nodules were collected from March 2014 to December 2014 in the department of vascular and thyroid surgery in the First Affiliated Hospital of Xinjiang Medical University and 315 cases of normal thyroid from health examination were collected form the Second Affiliated Hospital of Xin-jiang Medical Universitas control.The general information,urine iodine and blood selenium expression level were recorded for statistical analysis.Results Three groups of urine iodine level difference was sta-tistically significant (Z = 186.52,P <0.001).Compared with benign thyroid nodules group and thyroid normal group,thyroid cancer group urine iodine level were high,and the differences were statistically sig-nificant (Z =186.52,P <0.001).The differences of the blood selenium levels in three groups were were statistically significant (F =85.723,P <0.001).The blood selenium levels in thyroid cancer group and be-nign nodules group were lower than that in the normal thyroid group,and the differences were statistically significant (Z value of 10.681 and 8.459 respectively,P <0.001).The proportion of thyroid cancer in high urinary iodine with low blood selenium research objects were higher than that in the pure high urinary io-dine (χ2 = 11.322,P = 0.001 ).Compare with the pure low blood selenium objects,the proportion of thyroid cancer in high urinary iodine with low blood selenium research objects was not statistically signifi-cant (χ2 =0.000 076,P =0.993).Conclusion In Xinjiang Urumqi region,high urinary iodine with low blood selenium levels may be thyroid cancer related factors of the disease.Iodine and selenium may act syn-ergistically in the occurrence and development of thyroid cancer,which can by controlling the iodine intake and increase selenium nutrition status to the prevention and treatment of thyroid nodules,but need further research to determine the optimum nutrition level of selenium in Urumqi region.%目的：探讨乌鲁木齐地区人群碘和硒营养状态与甲状腺癌的相关性。方法收集2014年3－12月新疆医科大学第一附属医院血管甲状腺外科甲状腺癌患者140例（甲状腺癌组）及良性甲状腺结节患者147例（甲状腺良性结节组），另收集同期于新疆医科大学第二附属医院行甲状腺超声提示甲状腺形态正常的健康体检者315例（甲状腺形态正常组），测定3组人群尿碘和血硒水平，并进行统计学分析。结果3组尿碘水平差异有统计学意义（Z ＝186．52，P ＜0．001），甲状腺癌组尿碘水平较甲状腺良性结节组和甲状腺形态正常组高。3组血硒水平差异有统计学意义（F ＝85．723，P ＜0．001）。甲状腺癌组血硒水平较甲状腺良性结节组和甲状腺形态正常组低。甲状腺癌在高尿碘合并低血硒的研究对象中所占的比例高于单纯高尿碘和单纯低血硒的研究对象，其与单纯高尿碘者的差异有统计学意义（χ2＝11．322，P ＝0．001），与单纯低血硒者的差异无统计学意义（χ2＝0．000076，P ＝0．993）。结论新疆乌鲁木齐地区高尿碘和低血硒水平可能是甲状腺癌发病的相关因素，碘和硒在甲状腺癌的发生和发展中可能起着协同作用，可以通过控制碘摄入和提高硒营养状态来防治甲状腺结节，但需进一步研究确认乌鲁木齐地区硒的最适营养水平。
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