墨玉县农村维吾尔族慢性牙周炎与慢性肾脏病随访研究

摘要

目的 分析墨玉县农村维吾尔族居民6年间牙周炎与慢性肾脏病患病率的演变情况和相关因素,为慢性牙周炎和慢性肾脏病的防治提供依据.方法 2007年采用多阶段分层抽样的方法对墨玉县1415名维吾尔族成人进行慢性肾脏病和慢性牙周炎及相关危险因素的横断面调查,2013年对2007年资料完整的人群再次进行随访调查.2次调查均进行进行问卷调查、体格检查、口腔专科检查、实验室检查,采用多因素回归分析慢性肾脏病的危险因素.结果 2007-2013年牙周炎患病率由66.0%增加至79.6%,中度牙周炎(13.7%vs23.7%)和重度牙周炎(26.0%vs38.9%)患病率升高(P=0.000).2013年抽样人群慢性肾脏病患病率呈增加趋势(7.1%vs9.6%).牙周炎人群慢性肾脏病患病率由9.1%上升至11.5%.重度牙周炎组慢性肾脏病的患病率由14.9%增至17.3%,中度牙周炎组慢性肾脏病的患病率由5.7%增至6.2%.校正慢性肾脏病的相关危险因素后,年龄≥60岁、高血压(3级)和重度牙周炎是慢性肾脏病的危险因素,其中重度牙周炎组患慢性肾脏病的风险是非牙周炎组的4.4倍(95%CI:2.3~8.4).结论 墨玉县农村维吾尔族牙周炎患病率高,中、重度牙周炎患病率有升高趋势,重度牙周炎是慢性肾脏病患病的危险因素.%Objective To investigate the association between chronic periodontitis (CP) and Chronic Kidney Disease (CKD) for six-year longitudinal study in Moyu county, thereby producing scientific evidence to support strategies for the prevention and control of CP and CKD.Methods A longitudinal and observational study was conducted in 15 villages of Moyu county from 2007 to 2013.Two investigations were conducted in 2007 and 2013, respectively.All subjects received questionaire,physical examination,dental examination and biochemical analysis.The variables analyzed included epidemiology and laboratory data.Multivariate Regression model was used to evaluate risk for CKD.Results Investigation showed that the prevalence of chronic periodontitis significantly increased in the past six years (66.0% vs 79.6%, P=0.000), especially for severe periodontitis (26.0% vs 38.9%) and moderate periodontitis (13.7% vs 23.7%).The prevalence of CKD in the study population was increased from 7.1% to 9.6% for six-year follow-up, while the prevalence of CKD was significantly much higher in periodontitis group than that in non-periodontitis group (9.1% vs 11.5%),(P=0.000).The prevalence of severe periodontitis group with CKD was increased from 14.9% to 17.3% during 2007 to 2013, much higher than that in the moderate periodontitis group (5.7% vs 6.2%).Adjusting for the traditiona risks of CKD,we found subjects with severe peridontitis had a 4.4 times (95%CI:2.3~8.4)risk of CKD in comparision with non-periodontitis.Conclusion The study confirms a high prevalence of periodontitis in Uygur rural people in Moyu county, especially moderate and severe periodontitis were significantly more prevalent among them after 6 years longitudinal observation.Severe periodontitis was shown to be the risk factor of CKD.