Reconstruction of Mandibular Defect with Porous β-TCP/BMG Artificial Bone

摘要

The purpose of this study is to explore the feasibility of repairing mandibular defect with osteoconductive porous beta-tricalcium phosphate(β-TCP) combined with osteoinductive bone matrix gelatin(BMG), which has good physical property and biocompatibility and maybe a new type of artificial bone substitute. Bilateral mandible defects sized 1.0 cm×0.6 cm×0.3 cm of fifteen rabbits were implanted with β-TCP (control group) and β-TCP/BMG(experimental group) respectively. The specimens were harvested at 4 th, 8 th and 12 th weeks post-operation and examined by gross, X-ray, histomorphological and the computer analysis. The volume of newly-formed bone of the experimental side was much more than that of the control side at 4 th, 8 th and 12 th weeks. There is significant difference (p<0.05) between experimental group and control group. Computer-aided X-ray analysis showed that the density of newly-formed bone, compared with the control side, were similar to the surrounding natural bone at 12 th week after operation. Therefore, β-TCP/BMG is a better bone substitute than TCP and is a degradable and biocompatible artificial bone substitute material and is osteoinductive and osteoconductive.