不同饮酒量对脂肪肝患者肝功能和糖代谢的影响

摘要

目的:比较不同饮酒量对脂肪肝患者肝功能和糖代谢的影响.方法:选取体检中心、门诊及病房确诊为脂肪肝的患者,根据饮酒量分为不饮酒组、适量饮酒组、过量饮酒组,比较患者一般情况、肝功能指标和糖代谢指标.结果:共收集207例脂肪肝患者,其中适量饮酒组62例,不饮酒组75例,过量饮酒组70例.适量饮酒组收缩压显著低于另外2组,舒张压显著低于过量饮酒组,体质量指数(BMI)及腰臀比(WHR)低于另外2组(P＜0.05).适量饮酒组丙氨酸转氨酶(ALT)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)低于另外2组(P＜0.05),高密度脂蛋白(HDL-C)高于另外2组(P＜0.05).适量饮酒组糖化血红蛋白(HbA1c)、HOMA-IR低于另外2组(P＜0.05),胰岛素作用指数(IAI)高于另外2组(P＜0.05).结论:脂肪肝患者适量饮酒可以从血压、BMI、WHR、肝功能、心血管、胰岛素抵抗等方面获益.%Objective: To compare the effects of different alcohol consumptions on liver function and glu-cose metabolism in fatty liver patients. Methods: The patients diagnosed with fatty liver from physical examina-tion center, outpatient services and inpatient department, were divided into 3 groups: non-drinking group, mod-est-drinking group and heavy-drinking group according to the amount of alcohol consuming. Then, the details of patients' information include general physical condition, liver function and glucometabolic index were compared. Results: A total of 75 non-drinking patients, 62 modest-drinking patients, 70 heavy-drinking patients were col-lected. The modest-drinking group had a significantly lower level of systolic blood pressure (SBP) compared with other two groups and a significantly lower level diastolic blood pressure (DBP) compared with heavy-drinking group (P＜0.05). In the comparison of body mass index (BMI) and waist-hip ratio (WHR), the modest-drinking group was the smallest (P＜0.05). The modest-drinking group had significantly lower alanine transaminase (ALT), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and significantly higher high-density lipoprotein cholesterol (HDL-C) than those of other two groups (P＜0.05). The modest-drinking group had significantly lower hemoglobin A1c (HbA1c) and homeostasis model assessment-insulin resistance (HOMA-IR), significantly higher insulin action index (IAI) than other two groups (P＜0.05). Conclusion: Compared with the patients of non-drinking group and heavy-drinking group, the patients in modest-drinking group could benefit from blood pressure, BMI, WHR, liver function, cardiovascular system, insulin resistance and so on.