局部晚期直肠癌新辅助放化疗疗效与血管内皮生长因子水平的关系

摘要

Objective: To investigate the relationship between levels of serum vascular endothelial growth factors (sVEGF) and effectiveness of neoadjuvant chemoradiotherapy on locally advanced rectal cancer. Meth-ods: Levels of sVEGF were measured by enzyme-linked immunosorbent assay (ELISA) before and after treat-ment in 58 patients with locally advanced rectal cancer. The relationship between levels of sVEGFs and response of neoadjuvant chemoradiotherapy was analysed. Results: Levels of sVEGF were significantly decreased after treatment (P＜0.01). Levels of sVEGF were different among patients with different pathological grades (P＜0.05). Conclusion: The change of sVEGF level is able to evaluate the effectiveness of neoadjuvant chemoradiotherapy on locally advanced rectal cancer.%目的:探讨局部进展期直肠癌新辅助放化疗敏感性与血清血管内皮生长因子(sVEGF)水平的关系.方法:应用酶联免疫吸附法(ELISA)检测58例局部进展期直肠癌患者治疗前、后sVEGF水平,并分析其与新辅助放化疗疗效的关系.结果:治疗后患者sVEGF水平均有显著降低(P＜0.01),不同病理分级患者sVEGF表达水平差异有统计学意义(P＜0.05).结论:sVEGF水平的变化可作为局部进展期直肠癌新辅助放化疗的疗效评价的参考.