三苯双脒治疗肠道线虫感染的临床研究

摘要

Objective To study the effect of tribendimidine on treating cases with intestinal nematodes and its side effects. Methods 180 cases over two years old who had single or mixed infections with hookworm,roundworm, whipworm and pinworm were randomly grouped,and treated with tribendimidine in the trial group and albendazole in the control group, respectively. A single dose of 400 mg and 200 mg tribendimidine was used for adults and children younger than 14 years old, who infected with hookworm and pinworm, respectively. A single dose of 300 mg tribendimidine was given to cases infected with roundworm. The cases with whipworm infection were administered daily 400 mg tribendimidine for three days. The control cases received a single dose of 400 mg albendazole . One month after treatment, the therapeutic effects and side effects of two antihemintic drugs were observed. Results The cure rates for tribendimidine and albendazole for hookworm were 73.9% (17/25) and 50.0% (9/18), respectively; for roundworm were 85.7% (18/21) and 90% (10/11), respectively; for pinworm were 84.9% (28/33) and 100.0% (18/18), respectively. There was no statistical significance in the anthelminitc effect on the above-mentioned parasites between two drugs (p＞0.05). But the cure rate of tribendimidine for whipworm (25.0%) is statistically lower than that of albendazole(75%)(p＜0.05). The incidence of side effects in tribendinidine was few and mild, and no obvious influences on hemogram, hepatic or renal function, or on EKG. Conclusion The tribendimidine had marked antihelmintic effects against hookworm, roundworm and pinworm, but less effects against whipworm than albenazole.%目的 观察三苯双醚治疗人体肠道线虫感染的临床效果及其副作用.方法 180例2岁以上钩虫、蛔虫、蛲虫和鞭虫单独或混合感染者分组分别用三苯双醚和阿苯达唑治疗.成人及14岁以下儿童的钩虫和蛲虫感染者分别给三苯双醚40mg和200mg,蛔虫感染者给三苯双醚300mg,鞭虫感染者每天400mg三苯双醚,连续3天.各感染对照组均给予阿苯达唑400mg.同时观察三苯双醚及阿苯达唑的临床治疗的副作用.结果 三苯双醚和阿苯达唑对钩虫感染的治愈率分别为73.9%(17/25)and 50.0%(9/18).两药物对蛔虫感染的治愈率分别为85.7%(18/21)and 90%(10/11).两药对蛲虫感染的治愈率分别为84.9%(28/33)and 100.0%(18/18).三苯双醚的临床副作用轻微,对外周血象,肝、肾功能及心电图没有显著的影响.结论 三苯双醚对钩虫、蛔虫和蛲虫感染有显著的疗效,对鞭虫作用较差.