Objective To study the effect and security of Phentolamine on chronic pulmonary heart dis-ease with right ventricular dysfunction. Methods 92 cases with chronic pulmonary heart disease and right ven-tricular dysfunction in the 105th Hospital of PLA from June 2012 to June 2013 were selected and divided into two groups randomly. The control group (46 patients) was treated by spasmolysis, cardiac, expectorant, infec-tion control and improvement of heart function, and the treatment group by the same therapies as control group and intravenous infusion of phentolamine(20mg) additionally. The treatment duration of the two groups were all 10 days. Then the cardiac function, pulmonary artery pressure and right ventricular diameter change of the two groups between pre-treatment and post-treatment were analyzed, the effect of Phentolamine was eval-uated and the rate of adverse reaction were observed. Results There were significant differences of cardiac function, pulmonary artery pressure and right ventricular diameter between pre-treatment and post-treatment of the two groups (P<0.05). The effective rate of treatment group (91.30%) was higher than control group (80.43%) (P<0.05), and there was no significant difference in the adverse action between the two groups ( P>0.05). Conclusion The conventional therapy plus phentolamine on treatment of chronic pulmonary heart dis-ease with right ventricular dysfunction was efficacious, safe and worthy of promotion.%目的：研究酚妥拉明治疗慢性肺源性心脏病伴右心功能不全的效果及安全性。方法选择解放军第一五医院2012年6月~2013年6月就诊的慢性肺源性心脏病伴伴右心功能不全患者92例，采用数字随机表法分为两组，常规组46例采用解痉、强心、祛痰、感染控制和改善心功能等治疗，酚妥拉明组46例患者在常规组治疗基础上加用20mg酚妥拉明静脉滴注，两组患者均进行10d的治疗，对两组患者治疗前后心功能、肺动脉压、右心室内径改变情况进行分析，对治疗效果进行评价，同时观察两组不良反应发生率。结果两组治疗后心功能、肺动脉压、右心室内径均较治疗前显著改善，差异有统计学意义（P<0.05）；酚妥拉明组治疗后心功能Ⅰ级22例，心功能改善情况显著好于常规组，肺动脉压、右心室内径降低幅度显著大于常规组；酚妥拉明组总有效率为91.30%，对照组总有效率为80.43%，两组比较差异有统计学意义（P<0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论在常规治疗基础上加用酚妥拉明治疗慢性肺源性心脏病伴右心功能不全患者疗效好，安全性高，值得临床推广。
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