体外循环后肠功能障碍的研究进展

摘要

肠道是应激反应的中心器官和重要靶器官之一,肠黏膜屏障功能损害可以引起内毒素易位,并导致全身炎症反应以及多器官功能障碍.而体外循环(cardiopulmonary bypass,CPB)对机体是非常强烈的应激反应,近年来CPB引发的肠功能障碍引起日益关注.本文从CPB后肠黏膜屏障损害的机制及年龄相关性及目前中西医对CPB后肠功能障碍的保护等方面进行综述.%Intestine is the center of stress response and one of the important target organs. The impairment of intestinal barrier can lead to the translocation of endotoxin, resulting in the systemic inflammatory response and multiple organ dysfunction. Cardiopulmonary bypass ( CPB) may induce strong stress response in the body. The CPB-induced bowel dysfunction has drawn more and more attention recently. This paper reviews the intestinal mucosal barrier injury after CPB and its mechanisms, as well as the protection of CPB-induced intestinal injury by Chinese and Western medicine.