6-全脱氧-6-全氯代-β-环糊精的合成及自组装行为

摘要

In order to obtain the molecule with a needed structure,the modifiedβ-cyclodextrin,per(6-chlorin-6-deoxy)-β-cyclodextrin,was synthesized through the reaction of β-cyclodextrin,benzenesulfonyl chloride and imidazole in N,N-dimethylformamide(DMF).Its molecular structure was measured by X-ray crystallography,1H NMR spectroscopy,and thermogravimetric analysis(TGA).The crystal structure shows that the molecules of the compound are aligned on the a-axis to form a linear superstructure through head-to-head interactions at the primary side and tail-to-tail interactions at the secon-dary side.At the primary side,the chlorine atoms,through Cl—Cl interaction and that of hydrogen bonds,form hydropho-bic layers ,and at the secondary ,the hydroxyl groups interact through hydrogen bonds to form hydrophilic lay-ers.Thermogravimetric analysis shows that the different thermodynamic character results from the weakening of the interac-tion between the adjacentβ-cyclodextrins.%为了获得需要的结构分子，利用β–环糊精、咪唑和苯磺酰氯反应合成了6–全脱氧–6–全氯代–β–环糊精。通过X 射线衍射分析、核磁光谱及热重分析等方法进行了表征。晶体结构显示，化合物分子利用β–环糊精小口端的头–对–头相互作用以及大口端的尾–对–尾相互作用沿着 a 轴进行排列，形成线状超结构，其中在小口端通过 Cl—Cl 相互作用和氢键作用形成了疏水层，而在大口端通过羟基之间的氢键形成了亲水层。热重分析结果表明β–环糊精分子间相互作用的减弱导致化合物不同的热力学特性。