大承气汤颗粒剂对细菌性腹膜炎大鼠小肠组氨酶活性的影响

摘要

目的：观察大承气汤颗粒剂对细菌性腹膜炎大鼠小肠组氨酶活性的影响。方法：将健康大鼠58只随机分为实验性腹膜炎模型组(简称模型组)；正常对照组；及大承气汤颗粒剂大、中、小剂量组、大承气汤颗粒剂与头孢克罗联用组(简称联用组)和头孢克罗组；除模型组和对照组其他各组给药3d后，给予模型组和各给药组大肠杆菌悬液腹腔注射，造成细菌性腹膜炎，24h后将所有各组动物处死制得小肠匀浆标本测其组氨酶活性。结果：模型组与正对照组比较，组氨酶活性明显降低(P＜0.01)；给药组与模型组比较除大承气汤小剂量组和头孢克罗组，其余各组组氨酶活性均明显升高(P＜0.05)，且大承气汤颗粒剂对组氨酶活性的影响呈剂量依赖性。结论：大承气汤颗粒剂对肠道屏障有重要的保护作用。%Objective: To observe the effect of Dachengqi Decotion(Dcqc) particulate preparation on small intestinal histaminase activity of rats with bacterial peritonitis. Methods: Rats (n=58) were divided into model group、 normal control group、 Dcqc treatment group、 And cefaclor . The treatment groups were given Dcqc, excepting normal control group, the rats of every group were given escherichia coli suspension(i. p) . Rats suffer from bacterial peritonitis.24 hours later, all rats were killed and prepared well-distrubuted pulp sample of small activity.Results: Comparing with control, the histaminase activity of model group decreases significantly(P＜0.01); comparing with model group, the histaminase activities of all groups increase obviously(P＜0.05) except the small dosage group of Dcqc particulate preparation and cefalor group;the resulte indicate that the effect of Dcqc particulate preparation on histaminase activity is dosage dependent. Conclusion: Dcqc particulate has the important protective effect to the barriers of intestine.