中老年男性2型糖尿病患者骨质疏松症与血清胆红素的相关性

摘要

Objective:To investigate the relationship between serum bilirubin levels and osteoporosis (OP) in middle and old aged male patients with type 2 diabetes mellitus (T2DM). Methods:The included 125 male patients with T2DM were divided to the osteoporosis group and the non-osteoporosis group according to BMD values. The following risk factors of the two groups were compared:the duration of T2DM, age, body mass index (BMI), liver and renal function and the correlations between the above risk factors with BMD in T2DM complicated by osteoporosis were analyzed. Results:The prevalence of osteoporosis and osteopenia in the middle and old aged male patients with T2DM was 57.6%,duration of diabetes, age, BMI, TBIL, ALT and BUN were significantly different between the two groups. TBIL were negatively correlated with the prevalence rate of osteoporosis and positively correlated with BMD. Multiple logistic regression analysis showed that low TBIL was an independent risk factor of OP in middle and old-aged male diabetic subjects. Conclusion:Bilirubin levels are significantly associated with OP in middle and old-aged male with T2DM and bilirubin may protect against OP in diabetic men.%目的:探讨2型糖尿病(T2DM)患者血清胆红素水平与骨质疏松症的相关性.方法:选择125例住院治疗的中老年男性2型糖尿病患者,测量其骨密度(BMD)值,据此将研究对象分为两组:合并骨量减少或骨质疏松组(OP)和正常骨密度组(NOP).比较两组血清胆红素水平,并对胆红素和骨质疏松症的患病率及BMD进行相关性分析.结果:中老年男性T2DM合并OP的患病率为57.6%,统计学分析显示OP组与NOP组糖尿病病程、年龄、BMI、总胆红素(TBIL)、谷氨酸转氨酶(ALT)和尿素氮(BUN)水平存在显著差异,TBIL与骨质疏松患病率呈负相关,与各部位BMD呈显著正相关. Logistic多因素回归分析显示低TBIL水平是中老年男性T2DM患OP的独立危险因素. 结论:胆红素轻度升高是中老年男性T2DM骨质疏松症的一个重要保护因素.