光敏抗菌型静电纺丙烯酸甲酯/丙烯酸纳米纤维的制备及其性能表征

摘要

Polymethyl methacrylate-co-methacrylic acid (P(MMA-co-MAA)) synthesized by emulsion polymerization was electrospun into nanofibers,and carboxyl groups were used to adsorb cationic photosensitizers to fabricate photodynamic antimicrobial nanofibrous membrane.Gel permeation chromatography,Fourier transform infrared spectrometry,and thermo-gravimetric analysis were employed to characterize P(MMA-co-MAA) polymer.Scanning electron microscope and surface tension meter were used to analyze the surface morphology of the P (MMA-co-MAA) nanofibrous membrane as well as its adsorption behavior of cationic photosensitizers.Finally,the antimicrobial behavior of the as-prepared material was evaluated.The results indicate that P(MMA-co-MAA) polymers with relative high molecular weight as well as favorable spinnability are successfully prepared.Furthermore,the electrospun P(MMA-co-MAA) nanofibrous membrane shows good adsorption capacity of two cationic photosensitizers,i.e.,methylene blue (MB) and (meso-tetrakis (N-methylpyridinium-4-yl) porphyrin) Zn (Ⅱ) (Zn-Por).The membrane decorated by Zn-Por and MB shows desirable antimicrobial effect,and the sterilization ratio can reach 99.99％.%为利用乳液聚合法合成甲基丙烯酸甲酯与甲基丙烯酸共聚物(P(MMA-co-MAA)),通过静电纺丝技术制备P(MMA-co-MAA)纳米纤维膜,并利用其表面的羧酸基团吸附阳离子光敏药物,从而得到光敏抗菌型静电纺纳米纤维膜.通过凝胶渗透色谱、傅里叶红外光谱、热失重分析法等对P(MMA-co-MAA)聚合物进行表征,借助扫描电子显微镜、表面张力仪对P(MMA-co-MAA)纳米纤维膜的形貌及吸附行为进行分析,最后探讨了所制备纳米纤维膜的抗菌性能.结果表明:制备出了具有较高分子质量的P(MMA-co-MAA)聚合物,静电纺纳米纤维膜对阳离子光敏剂亚甲基蓝(MB)和5,10,15,20-四(4-N-甲基吡啶基)卟啉锌(锌卟啉)具有良好的吸附性能.二者都表现出良好的抗菌效果,抗菌率可达到99.99％.