广州市社区人群非心源性胸痛的流行病学调查

摘要

[Objective] To evaluate the population-based prevalence and risk factors of noncardiac chest pain (NCCP) in Guangzhou, China. [Methods] In September 2009, a multi-stage sampling survey (face-to-face interview) was carried out in Nonglin Community, Guangzhou, using the Rose Angina Questionnaire and a validated Chinese version of Reflux Disease Questionnaire. Chi-square test or Fisher's exact test were performed to analyze the categorical variables. Risk factors for NCCP were identified using multiple logistic regression analysis. [Results] A total of 1 707 residents (male 814, female 893) were investigated with the response rate of 100%. Mean age of the subjects was 51 (S = 18) years. Chest pain over the past year was present in 92 subjects (5.4%, 95% CI 4.3%-6.5%), while NCCP was present in 61 subjects (3.6%, 95%CI 2.7%-4.5%). The prevalence of NCCP was higher in women than in men (4.8% vs 2.2%,x2 = 8.379,P = 0.004). Among those with NCCP, 8.2% had experienced heartburn and/or acid regurgitation,and 47.5% had history of hypertension. By multiple logistic regression analysis with gender and age adjustment, presence of heartburn and/or acid regurgitation (OR =3.8,95% CI 1.1 -12.9,P = 0.034), non-steroidal anti-inflammatory drug (NSAID) usage (OR = 10.5, 95%CI 5.1-21.7, P< 0.001), and hypertension (OR = 2.7, 95%CI 1.4-5.2, P= 0.003) were risk factors associated with NCCP. [Conclusions] NCCP is common in the general population in Nonglin Community, Guangzhou. Heartburn and/or acid regurgitation, NSAID usage and hypertension may be risk factors associated with NCCP.%[目的]了解广州市社区人群中非心源性胸痛(NCCP)的患病情况，探讨相关危险因素。[方法]2009年9月，采用多阶段抽样方法在广州市农林街社区进行入户面访式问卷调查，内容包含Rose心绞痛问卷和中国反流性疾病问卷等。采用x2检验或Fisher确切概率法比较率的差异，多变量logistic回归分析探讨NCCP相关危险因素。[结果]实际调查1707人(男814人，女893人)，应答率100％。平均年龄51(S=18)岁。过去1年中出现胸痛者共92人(5.4％，95％CI4.3％～6.5％)，61人(3.6％，95％CI 2.7％～4.5％)出现NCCP，NCCP患病率女性高于男性，分别为4.8％和2.2％(x2=8.379，P=0.004)。NCCP人群中8.2％出现烧心和(或)反酸症状，47.5％有高血压病史。多变量logistic回归分析显示，在控制了年龄和性别的影响后，NCCP的危险因素有：烧心和(或)反酸(OR=3.8，95％CI 1.1～12.9，P=0.034)，服用NSAID(OR=10.5，95％CI 5.1～21.7，P＜0.001)，高血压(OR=2.7，95％CI 1.4～5.2，P=0.003)。[结论]广州市农林街社区人群中NCCP常见。烧心和(或)反酸，服用NSAID和高血压是NCCP可能的危险因素。