大株红景天注射液与丹红注射液治疗冠心病心绞痛的疗效对比

摘要

目的：对比分析大株红景天注射液与丹红注射液治疗冠心病心绞痛临床疗效。方法将2010年3月～2014年3月南京医科大学附属江宁医院收治的128例冠心病心绞痛患者随机分为A、B两组各64例，两组均进行常规治疗，在此基础上A组给予大株红景天注射液静滴治疗；B组给予丹红注射液静滴治疗，10天为1个疗程。分别记录10天内患者用药前后心电图分析、心绞痛次数、血浆D－二聚体和纤维蛋白原含量，并记录治疗过程中出现的不良反应。结果大株红景天注射液与丹红注射液对冠心病心绞痛均有一定的缓解作用，且大株红景天注射液较丹红注射液对症状的缓解效果好，差异具有统计学意义（P＜0．05），而两组缺血性恢复效果差异无统计学意义（P＞0．05）；两组患者在一定程度上均降低了血浆纤维素蛋白原含量，且A组降低效果强（P＜0．05），而两组降低血浆中D－二聚体含量的效果无统计学差异（P＞0．05）；治疗过程中均未见不良反应。结论大株红景天注射液较丹红注射液治疗冠心病心绞痛的综合疗效更显著。%Objectives To compare and analyze the clinical efficacy of Dazhu Hongjingtian Injection and Danhong Injection in the treatment of angina pectoris of coronary heart disease ( CHD) .Methods A total of 128 patients with angina pectoris of CHD admitted in our hospital from March 2010 to March 2014 were selected and randomly divided into group A and group B, 64 cases in each group.Both groupswere treated with routine therapies, on which basis group A was added with Dazhu Hongjingtian Injection while group B with Danhong Injection, 10 days as a cycle.Electrocardiographic analysis, angina pectoris frequency, plasma D-di-mer and fibrinogen contents were recorded before and after drug administration within 10 days and adverse responses during treatment were observed in both groups.Results Both Dazhu Hongjingtian Injection and Danhong Injection had certain alleviating effect on angina pectoris of CHD, and Dazhu Hongjingtian Injection was markedly better than Danhong Injection in relieving symptoms ( P<0.05), but there was no significant difference between two groups in ischemic recovery (P>0.05).Both groups could reduce blood fibrinogen content to some extent, and group A was prominently better than group B (P<0.05), but there was no significant differ-ence in reducing blood D-dimer content ( P>0.05 ) .No adverse response was observed in both groups.Conclusions Dazhu Hongjingtian Injection is superior to Danhong Injection in comprehensive clinical efficacy.