RUNX3蛋白在肝癌组织中的表达及其意义

摘要

目的 探讨RUNX3蛋白在肝癌组织及其癌旁组织中的表达情况,并分析其与临床病理因素的相关性.方法 采用免疫组织化学法检测RUNX3蛋白在肝癌组织及其癌旁组织中的表达水平,并分析其与临床病理因素的相关性.结果 RUNX3蛋白在肝癌组织、癌旁组织中的表达阳性率分别为49.02%(25/51)、82.35%(42/51),两者间有显著差异(x2=12.5706,P＜0.01).RUNX3蛋白在分化程度、门静脉癌栓、肝内转移等病理因素的表达差异有统计学意义(P＜0.05),而在性别、肿瘤直径、肿瘤部位、癌肿出血坏死、组织分型的表达差异无统计学意义(P＞0.05).结论 RUNX3蛋白在肝癌组织中的表达水平明显低于癌旁组织.RUNX3蛋白表达下调可能对肝癌的发生、发展具有重要作用,RUNX3基因可能是肝癌的抑癌基因.%Objective To evaluate the effects of pulse high volume hemofiltration (PHVHF) in the treatment of multiple organ dysfunction syndrome (MODS). Methods Twenty-five patients with MODS received treatment with PHVHF. Results The 25 patients showed significantly decreased BUN, Scr, and K- levels after the treatment (P<0.01), and PaOz/ FiO2 was improved in almost all the patients (P<0.05). The APACHEII scores were significantly improved (P<0.05) in these patients and 18 of them were cured and discharged. PHVHF therapy was associated with a survival rate of 72%. Conclusion PHVHF can be effective for treatment of MODS.