NMDAR、NR2A、NR2B与糖尿病认知功能障碍的关系

摘要

糖尿病认知功能障碍（CID）是糖尿病的严重慢性并发症之一，其发病机制目前尚未完全清楚。近年来，人们发现N-甲基-D-天冬氨酸受体（NMDAR）及其亚基NR2A、NR2B不仅参与中枢神经系统的发育和学习记忆的形成，且其分布及表达与CID的发生、发展密切相关。%Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus, and its pathogenesis has not yet been fully understood. Increasing evidence has shown that the distribution and expression of N-methyl-D-aspartame receptor (NMDAR) and subunits NR2A and NR2B, which all participated in the development of the central nervous system and formation of learning and memory, are correlated with the occurrence and development of CID.