目的 在非糖尿病正常体质量人群中探讨腰臀比与胰岛素抵抗的相关性,比较其在不同性别的差异.方法 选择2012年6月~10月我国南方社区居民进行横断面筛查(n=2142).将参与者分为男性组和女性组,并按腰臀比四分位数将男女各分为4组.HOMA-IR=[空腹血糖(FIG)x空腹胰岛素(FINS)]/22.5,HOMA-IR做为胰岛素抵抗的评价指标.建立Logistic回归模型分析正常体质量人群中腰臀比与胰岛素抵抗的相关性,并比较其在不同性别中的差异.结果 男性和女性正常体质量人群中胰岛素抵抗发生率分别为6.95%,11.47%.在女性非校正模型中,腰臀比与胰岛素抵抗显著相关(OR 6.60,95%CI 2.86 to 15.26,P<0.001),校正潜在混杂因素如高血压史、冠心病史、吸烟史、锻炼情况、BMI后,二者仍具相关性(OR 3.28,95%CI 1.34 to 8.04,P=0.009).结论 在非糖尿病正常体质量人群中,女性腰臀比是胰岛素抵抗的独立危险因素.%Objective To explore the relationship between waist-to-hip ratio (WHR) and insulin resistance(IR) in non-diabetic normal-weight individuals and investigate how this association differs between male and femalesubjects. Methods From June to October, 2012, we performed a cross-sectional survey among 2142 community-based non-diabetic Chinese participants, who were divided into 4 groups according to the gender-specific quartiles of WHR. Homeostatic model assessment of insulin resistance (HOMA-IR), calculated as the product of fasting plasma glucose (mmol/L) and fasting insulin (mU/L) divided by 22.5, was used as the indicator of insulin resistance. Logistic regression models were used to explore the association of WHR with IR in these subjects. Results In the unadjusted model, WHR was significantly associated with IR in women (OR=6.60, 95%CI: 2.86-15.26, P<0.001); the association was still significant (OR=3.28, 95%CI: 1.34-8.04, P=0.009) after adjustment for the potential confounders including the history of hypertension, coronary heartdisease, current smoker, physical inactivity, and body mass index. Conclusion WHR is independently associated with IR in non-diabetic Chinese women with normal body weight.
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