阿司匹林对维持性血液透析患者心脑血管事件的干预作用

摘要

目的：探讨对维持性血液透析（ MHD）患者应用阿司匹林降低心脑血管事件的疗效和安全性。方法：选取100例透析充分的MHD患者为研究对象，随机分为治疗组和对照组，每组50例，治疗组患者给予阿司匹林治疗。结果：与对照组比较，治疗组心脑血管事件发生率明显降低（ P＜0．05），出血事件无显著差异（ P＞0．05）。透析时间、血磷、spKt/V是MHD患者发生心脑血管事件的独立影响因素。结论：阿司匹林可有效降低MHD患者心脑血管事件发生，且危险性无显著增加。%Objective: To observe the efficacy of reducing cardiovascular events and safety in maintenance hemodialysis ( MHD) patients taked aspirin .Methods:100 cases of MHD patients with dialysis adequacy were randomly divided into treatment group and control group , 50 cases in treatment group were treated with aspirin . Results:The incidence of cardiovascular and cerebrovascular events in treatment group was significantly lower than control group(P<0.05).No significant difference was found in bleeding events between the two groups ( P >0.05).Duration of dialysis, phosphorus, spKt/V were independent factors of cardiovascular and cerebrovascular events in hemodialysis patients .Conclusion: Aspirin can reduce cardiovascular and cerebrovascular events in MHD patients , and have no significant increase in risk .