p53、Ki-67、PCNA的表达与食管鳞癌放疗近期疗效及预后的关系

摘要

Objective:To explore the expression of p53, Ki-67 and proliferating cell nuclear antigen(PCNA) in esophageal squamous cell carcinoma and its relation with radiotherapy effect and prognosis.Methods: Eighty-three esophageal carcinoma patients who underwent esophageal radiotherapy in our hosiptal were analyzed.Expressions of p53,Ki-67and PCNA were detected by immunohistochemistry, and its relation with clinicopathologic features, radiotherapy effect and survival rate of esophageal carcinoma patients was analyzed.Results: The positive expression rates of p53,Ki-67and PCNA were 57.8%,72.3%and 67.5%, respectively.The expressions of p53,Ki-67and PCNA in different gender,age,tumor position and size had no statistical differences(P>0.05).p53 was related to the tumor differentiation degree, clinical stage,lymph node metastasis and radiotherapy effect(P<0.05).Ki-67 was related to the tumor differentiation degree,lymph node metastasis and radiotherapy effect (P<0.05).PCNA was related to the clinical stage,lymph node metastasis and radiotherapy effect (P<0.05).Three years overall survival rates of patients in low and high p53 expression groups were 57.14% and 27.08%,respectively.Conclusion: p53, Ki-67 and PCNA can be used as the predictive markers for judguing malignant degree and radiosensitivity of esophageal carcinoma.p53 will be a useful marker for evaluating the prognosis of esophageal carcinoma.%目的:探讨食管鳞癌组织中p53、Ki-67及增殖细胞核抗原(PCNA)的表达与食管癌患者放疗近期疗效及预后的关系.方法:收集接受放疗的食管癌患者83例,采用免疫组化方法检测活检癌组织中p53、Ki-67及PCNA的表达,并分析其与临床病理特征、放疗疗效和预后的关系.结果:p53、Ki-67及PCNA在食管鳞癌中高表达率分别为57.8%、72.3%、67.5%.p53、Ki-67及PCNA表达与性别、年龄、侵犯部位、肿瘤长度等各临床病理因素无关(P>0.05),p53与肿瘤分化程度、临床分期、淋巴结转移、放疗近期疗效明显相关(P<0.05),Ki-67与肿瘤分化程度、淋巴结转移、放疗近期疗效明显相关(P<0.05),PCNA与临床分期、淋巴结转移、放疗近期疗效明显相关(P<0.05).p53低、高表达组食管癌患者3年总生存率分别为57.14%、27.08%.结论:p53、Ki-67及PCNA可作为评价食管癌恶性程度、放射敏感性的生物学指标,p53可作为评价食管癌预后的有效指标.