习惯性流产者血清抗子宫内膜抗体、同型半胱氨酸、叶酸及孕酮水平分析

摘要

Objective: To investigate the relationship between serum anti-endometrial antibody(EMAb), homo-cysteine(Hcy), folic acid, progesterone and habitual abortion.Methods: One hundred and twenty-three non preg-nant women with a history of recurrent spontaneous abortion ( two or more consecutive) treated in our hospital were selected as habitual abortion group.In the same period 123 cases of normal pregnant women ( NP group) and 123 cases of normal non pregnant women ( NNP group) were assigned to reference group.The results of EMAb, Hcy, folic acid and progesterone detection were analyzed and compared between the groups.Results: (1) The mean ser-um Hcy in habitual abortion group was significantly higher than that in the reference group.The mean folic acid and progesterone value were significantly lower than those in the reference group ,the differences bing statistically signifi- cant(P<0.05).(2)In NP group, Hcy was negatively correlated with folic acid levels (r＝-0.459, P＝0.012), while Hcy in the habitual abortion group was positively correlated with folic acid levels ( r＝-0388, P＝0.023). (3)The positive rate of EMAb in the habitual abortion group was higher than that of the two groups in the reference group with statistically significant difference (P<0.05).(4)Compared with the women less than 30 years old, the Hcy values in habitual abortion women of more than 30 years old were significantly higher and the levels of progest-eron decreased significantly , the differences being statistically significant ( P<0.05).Conclusion: The levels of EMAb, Hcy, folic acid and progesteron are associated with the outcome of early threatened abortion .%目的:探讨血清抗子宫内膜抗体(EMAb)、同型半胱氨酸(Hcy)、叶酸、孕酮水平与习惯性流产之间的关系.方法:选取我院妇产科门诊或住院者中至少有2次连续自然流产史的非孕期妇女123例作为习惯性流产组,同期正常妊娠的孕妇123 例(为正常妊娠组)和非妊娠育龄妇女123 例(为正常育龄组)作为参考组,对各组EMAb、Hcy、叶酸、孕酮水平检测结果进行比较.结果:(1)习惯性流产组的血清Hcy平均值明显高于参考组,叶酸平均值及孕酮值明显低于参考组,差异均有统计学意义(P<0.05). (2)正常妊娠组Hcy值与叶酸水平呈负相关(r＝-0.459,P＝0.012);习惯性流产组Hcy值与叶酸水平呈正相关(r＝-0388, P＝0.023). (3)习惯性流产组的EMAb阳性率高于两参考组(P<0.05). (4)与<30岁相比,≥30岁习惯性流产患者的Hcy值明显增高,孕酮值明显下降(P<0.05).结论:孕妇EMAb、Hcy、孕酮、叶酸水平与早期先兆流产有一定的关系.