组蛋白去乙酰化酶11的表达在霍奇金淋巴瘤中的临床病理意义初探

摘要

目的:探讨经典霍奇金淋巴瘤(classical Hodgkin lymphoma,cHL)组蛋白去乙酰化酶(histone deacetylase,HDAC) 11的表达及其与临床病理特征和预后的关系.方法:应用免疫组织化学方法检测56例cHL患者肿瘤组织中HDAC11的表达情况,并研究其与临床病理特征及预后的关系.结果:全组霍奇金-李-斯(Hodgkin-Reed-Steinberg,HRS)细胞中HDAC 11的表达14例阴性、28例弱阳性和14例阳性,结节硬化型共28例,高表达率21.4％;混合细胞型共22例,高表达率27.2％.HDAC 11在cHL的组织HRS细胞中的表达与性别、年龄、肿瘤分期、大肿块及B症状的关系不明显,与是否有结外累犯有明显关联(x2=8.185,P=0.011).56例cHL患者中位无进展生存期(progression free survival,PFS)为140个月(95％ CI为90.1 ～189.9)、总生存期(overall survival,OS)为108个月(95％ CI为96.0 ～119.9).HDAC 11阴性表达组的10年PFS大于HDAC11弱阳性组,也大于HDAC 11阳性组(分别为86％、70％和15％),两两比较差异有统计学意义(Log-rank检验P=0.013);HDAC11阴性组的10年OS大于HDAC11弱阳性组,也大于HDAC11阳性组(分别为100％、78％和45％),两两比较差异有统计学意义.结论:HDAC 11表达与cHL患者是否有结外累犯有关,与其他临床病理特征无关,HDAC11低表达是普遍现象,HDAC11表达增高与PFS及OS呈负相关.%Objective:To investigate the expression of histone deacetylase (HDAC) 11 in classical Hodgkin lymphoma (cHL) and its relationship with clinicopathological features and prognosis.Methods:I mmunohistochemistry was used to detect the expression of HDAC11 in tumor tissues from 56 cHL patients and further studied the relationship between the HDAC11 expression and clinicopathological features and prognosis.Results:Among all patients,14 cases were negative expression of HDAC11,28 cases weakly positive and 14 cases positive.In 28 cases of nodular sclerosis type,the high expression rate was 21.4％;in a total of 22 cases of mixed cell type,the high expression rate of 27.2％.The relationship between HDAC11 expressions of Hodgkin-Reed-Steinberg (HRS) in cHL tissue and the gender,age,stage,bulky disease and B symptoms were not significantly differences.The HDAC11 expression had a significant correlation to the extranodal infiltration (x2 =8.185,P =0.011).The median progression free survial (PFS) was 140 months (95 ％ CI 90.1-189.9) and overall survival (OS) was 108 months (95％ CI 96.0-119.9) in all 56 patients with cHL.Ten years PFS of HDAC 11 negative expression group was 86％,was more than that of HDAC 11 weak positive group(70％) and that of the HDAC11 positive expression group (15％),the difference was statistically significant (Log-rank P =0.013).Ten years OS of HDAC 11 positive expression group was 100％,was more than that of HDAC weak positive group(78％) and that of HDAC 11 negative expression group (45％),the difference was statistically significant.Conclusion:The expression of HDAC11 relates to the presence of the extranodal infiltration in cHL patients,and is not associated with other clinicopathological features.The low expression of HDAC11 is a co mmon phenomenon.The increased expression of HDAC11 is negatively correlated with PFS and OS in patients with cHL.