5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究

摘要

为探讨5-氟尿嘧啶的药效、毒性与给药剂量之间的关系,采用BALB/c小鼠来源的CT26结肠癌细胞株构建小鼠结肠癌模型,分别给予10、20、30和50 mg/kg剂量的5-氟尿嘧啶,分析其抗肿瘤效果、对小鼠体质量的影响和死亡率等指标.结果表明,5-氟尿嘧啶的体内抑瘤效果及毒性与剂量密切相关.综合分析评价各指标,认为20～ 30 mg/kg剂量的5-氟尿嘧啶较适合于小鼠结肠癌模型中的药效评价.%To investigate the relationship of anticancer effects, toxicity and dose, tumor syngeneic models were made from murine colorectal adenooarcmoma cell line CT26 derived from BALB/c mice. Mice were treated with various doses (10, 20, 30 and 50 mg/kg) of 5-fluorouracil (5-FU) , and the indexes were analyzed, including the anti-tumorigenic effects, body mass and mortality of mice. The results showed that the efficacy and toxicity of 5 -FU was closely related to the doses, and the proposal dose was 20 - 30 mg/kg which may be the optimal dose for drug research in tumor syngeneic model of mice.