单环β-内酰胺碱性条件下开环反应机理的理论研究

摘要

Five mono cycle β Lactams’ structures were optimized by semi empirical AM1 method of quantum chemistry.The ring opening reaction mechanism of mono cycle β Lactams in the presence of base were studied.The geometric configurations of reaction transition states and reaction products were calculated.At the same time,the law of electronic transference in reaction was found.