Objective:To investigate the effects of Houttuynia cordata leaf extract damage of bone marrow hemato-poietic function and immune function in rats of X ray radiation. Methods:The rest of the successful model of 24 rats were randomly divided into 3 groups:model control group ( model group) , total flavone group and polysac-charide group, each having 8 rats. SLN were poured into the stomach volume of distilled water, total flavonoids extract 5. 23g/kg and polysaccharide powder suspension (2g/kg) gavage. Results:Fresh Houttuynia polysaccha-ride and total flavonoids can have a protective and therapeutic effect on rats injured by x-rays. Houttuynia corda-ta flavonoids can significantly increase the number of white cells, the spleen index and the content of bone mar-row DNA, with the micronucleus rate of red blood cell and the Micronucleus Rate of Bone Marrow Polychromatic Erythrocyte of rats decreased; it can increase the content of SOD and GSH-Px. Polysaccharide of Houttuynia cordata could remarkably increase the thymus index and spleen index of rats and the content of SOD, CAT and GSH-Px; it could significantly lower the peripheral blood and bone marrow micronucleus rate. Conclusion:Houttuynia cordata Thunb fresh leaves have a good anti-radiation effect with a different effect mechanism and di-versified effective parts of the body.%目的：探讨鲜鱼腥草叶提取物对X射线辐射损伤大鼠骨髓造血功能和免疫功能的影响.方法将造模成功的24只大鼠随机分为3个组，分别为模型对照组(模型组)、总黄酮组、多糖组，每组各8只，分别给予等体积的蒸馏水、总黄酮提取液(5．23g/kg)、和多糖粉末混悬液(2g/kg)灌胃.结果鲜鱼腥草多糖与总黄酮皆能够对受X射线辐射损伤的大鼠起到保护和治疗的作用；鱼腥草总黄酮成分可显著增加白细胞数，升高脾脏指数，增加骨髓DNA含量，降低外周血网织红细胞微核率和骨髓嗜多染红细胞微核率，可增加SOD及GSH-Px的含量；鱼腥草多糖可显著升高大鼠胸腺指数和脾脏指数，明显降低外周血和骨髓微核率，显著提高SOD、CAT和GSH-Px含量.结论鲜鱼腥草叶具有较好的抗辐射作用，其提取物的作用机制和作用的有效部位有所不同.
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