目的：探讨妊娠期系统性红斑狼疮( SLE)患者病情发展情况及其对妊娠结局的影响。方法根据妊娠期SLE病情活动情况将2010-01~2015-12首都医科大学附属北京世纪坛医院收治的20例SLE孕妇分为活动性SLE妊娠患者13例及非活动性SLE妊娠患者7例，对比分析两组患者妊娠并发症情况及妊娠结局。结果非活动性SLE妊娠患者的足月产率高于活动性SLE妊娠患者(P<0.05)；非活动性SLE患者的早产发生率低于活动性SLE妊娠患者(P<0.05)；非活动性SLE患者新生儿体重、平均分娩孕周均高于活动性SLE妊娠患者(P<0.01)；非活动性SLE患者的妊娠并发症发生率低于活动性SLE患者(P<0.01)，其中非活动性SLE患者中有0例发生子痫前期，活动性SLE患者中有10例患者发生子痫前期。结论系统性红斑狼疮患者活动期妊娠不良妊娠结局及妊娠并发症的发生率均高于非活动期妊娠。%Objective To explore the maternal and fetal outcomes of pregnancy in patients with systemic lupus erythematosus( SLE) . Methods The clinical data of 20 cases of pregnancy complicated with SLE were retrospectively analyzed. Twenty pregnant women complicated with SLE were divided into active phase(n=13) and inactive phase(n=7) according to the progression condition of SLE. The maternal and infantile complications and pregnancy outcomes in the two groups were compared and analyzed. Results The rate of full-term birth in pregnancy with inactive SLE was significantly higher than that in pregnancy with active SLE(P<0. 05), and the incidence of prematurity in pregnancy with inactive SLE was significantly lower than that in pregnancy with active SLE(P<0. 05). The fetal birth gestational age and body weight in pregnancy with inactive SLE were significantly higher than that in pregnancy with active SLE(P<0. 01), and the incidence of complications in pregnancy with inactive SLE was significantly lower than that in pregnancy with active SLE(P<0. 01). No preeclampsia occurred in inactive group, while 10 cases of preeclampsia were observed in active group, and there was significant difference between two groups(P<0. 01). Conclusion The incidence rate of adverse pregnancy outcome as well as the pregnancy complications in pregnant women complicated with SLE during active phase is relatively high, thus the guidance during gestational period should be strengthened among pregnant women complicated with SLE.
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