Objective To discussion on small‐dose 131 I treatment of hyperthyroidism difference in effica‐cy ,provide a reference for clinical treatment .Methods 64 patients with hyperthyroidism were divided into small doses of the observation group and the control group using conventional dose ,32 cases in each occur‐rence after 1 year of treatment were compared two groups of patients in the clinical effect and hypothyroid‐ism .Results The observation group were using low‐dose therapy ,the clinical total effective rate was 90 . 63% ,compared with 93 .75% in the control group of patients ,the difference was not statistically signifi‐cant ( P > 0 .05);the observation group were using low‐dose therapy ,its treatment during hypothyroid‐ism two cases (6 .25% ) (1 year ) occurred significantly less than the eight cases in the control group (25% ) ,the difference was statistically significant ( P<0 .05) .Conclusion Within reasonable limits ,small doses will not affect the clinical efficacy of 131 I ,and can effectively reduce the incidence of hypothyroidism is worthy of reference and widely used .%目的：探讨小剂量与常规剂量131 I治疗甲亢的疗效差异，为临床治疗提供参考意见。方法将64例甲亢患者分为使用小剂量的观察组和使用常规剂量的对照组，各32例，治疗1年后对两组患者的临床效果和甲减发生情况进行比较。结果观察组患者使用小剂量疗法，其临床总有效率为90．63％，与对照组患者的93．75％相比较，差异不具有统计学意义（ P ＞0．05）；观察组患者使用小剂量疗法后，其治疗期间（1年内）发生甲减2例（6．25％），显著低于对照组的8例（25％），差异具有统计学意义（ P ＜0．05）。结论在合理范围内，小剂量使用131 I不会影响临床疗效，且可有效降低甲减发生率，值得临床借鉴及推广使用。
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