猫儿屎内生真菌DL06次生代谢产物及抑菌活性的研究

摘要

Fourteen known compounds had been isolated from the Aspergillus.niger DL06 of Decaisnea fargesii.Their structures were identified by spectra and physicochemical properties analysis.Seven compounds were obtained and identified as 2-acetyl-4(3H)-quinazolinone (9),nicotinic acid (10),meleagrin (11),erythritol(12),fumaryl-L-alanine (13),daucosterol(14) and mannitol(14).The antimicrobial activity test of these 7 compounds'' showed that Compounds 9,10,11 and13 had good antibacterial activities against most of test bacteria.%从猫儿屎内生真菌产黄青霉DL06发酵物中分离出15个化合物,通过波谱数据、理化性质鉴定化合物结构.在原分离鉴定的基础上又分离鉴定出了7 个化合物,分别为2-乙酰基-4(3H)-喹唑啉酮(9)、烟酸(10)、meleagrin(11)、赤藓醇(12)、富马酰-L-丙氨酸(13)、胡萝卜苷(14)、甘露醇(15).并对分离出的7个化合物的抑菌活性进行测试,结果表明:化合物9、10、11、13对测试菌有不同程度的抑制作用.