卵泡刺激素/黄体生成素比值与卵巢反应性的关系

摘要

辅助生殖技术中,卵巢储备评估可以有助于预测超促排卵中的卵巢反应性.有学者认为卵泡刺激素/黄体生成素(FSH/LH)比值可以作为评估卵巢储备的指标,并与体外受精(IVF)前月经周期的长度和卵巢对FSH刺激的敏感性有关[1].来源于垂体的FSH和LH的分泌在正常的生殖周期中有不同的模式,它们调控卵巢生理功能的作用明显不同,其各自的分泌调控不同,因此它们的比值在不同的生理时期会发生不同的变化.了解FSH/LH的变化特点及其意义可以指导对该比值评估的临床应用和思考.在生殖内分泌领域中,FSH/LH对卵巢储备评估与卵巢反应性的预测意义吸引了同行的关注及研究探讨.本文就FSH/LH比值与卵巢反应性的关系作初步论述.%Basal follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio tends to be elevated as ovarian aging. The retrospective studies from IVF/ICSI data showed that FSH/LH ratio was associated with the ovarian response, and the proportion of poor response elevated when FSH/LH ratio> 3. The elevated basal FSH/LH ratio suggested the ovarian reserve diminishing. When FSH level was within'normal' range, the elevated ratio was due to low LH concentration. Among these patients with normal FSH and low LH level, the subclinical functional hypogonadotrophic hypogonadism was related to poor ovarian response, too. An appropriate protocol is needed for a better pretreatment of subclinical, functional hypogonadotrophic hypogonadism due to ovarian aging in order to achieve a good outcome of assisted reproduction.