An important influencing factor for pregnancy rate and pregnancy outcome in frozen embryo transfer cycles is the difficulty handling endometrial receptivity status. Appropriate endometrial progesterone(P) level is essential to endometrial receptivity. Progesterone is one of the most basic hormones to maintain endometrial receptivity in luteal phase. It is generally believed that progesterone threshold for endometrium luteinized is 3. 18-31. 8 nmol/L in mid-luteal phase. The serum progesterone level less than 47. 7 nmol/L in mid-luteal phase is often diagnosed as luteal phase defect. The data of the frozen-thawed embryo transfer cycles in our center from 2011 to 2012 suggested that it is of predictive value to detect progesterone level on the embryo transfer day. When P<15. 9 nmol/L on the embryo transfer day, the pregnancy rate was significantly decreased and abortion rate significantly increased in the patients with normal endometrium, and it would be better to cancel the transfer. When 15. 9 nmol/L≤P<47. 7 nmol/L on the transfer day,the pregnancy rate was lower and abortion rate higher than those in the patients with P≥47. 7 nmol/L, and the embryos could be transferred, but it needs to increase the amount of progesterone for luteal support to achieve pregnancy or improve the pregnancy outcome. The pregnancy rates was the highest and the abortion rate was the lowest in the patients with P≥47. 7 nmol/L on the embryo transfer day, but it also needs amount of progesterone to maintain the original luteal support.
展开▼
