Objective:To systematically review the correlation between PTEN expression and prostate cancer in Chinese population.Methods:All the studies regarding the correlation between PTEN expression and prostate cancer in Chinese population were collected from the databases,including PubMed,Embase,CBM,CNKI,VIP and Wanfang etc.Meta-analysis was performed using Revman 5.3 software,and the risk of bias was assessed according to the Newcastle-Ottawa Scale(NOS).Results:A total of 26 studies were included,involving 1025 patients with prostate cancer,461 patients with benign prostatic hyperplasia cases,and 37 controls.The results of meta-analysis showed that the prostate cancer group had a lower PTEN expression level compared with the benign prostatic hyperplasia group [OR=0.03,95％ CI(0.02,0.05),P＜0.01] and the control group[OR=0.03,95％CI(0.01,0.11),P＜0.01].Moreover,the expression level of PTEN was lower in the low and medium differentiation group than that in the high differentiation group [OR =0.20,95 ％ CI(0.15,0.27),P＜0.01].The expression of PTEN was significantly lower in the C+D staget than that in the A+B stage in JWP staging of prostate cancer [OR =0.11,95 ％ CI (0.08,0.16),P ＜ 0.01],and the expression was significantly lower in the prostate cancer with metastasis than without metastasis [OR=0.10,95 ％CI(0.05,0.19),P＜0.01].Conclusions:Current evidence indicates that the expression level of PTEN is significantly correlated with prostate cancer and its clinic pathologic features in Chinese population.Due to sample size and quality of included studies,the conclusion needs more large-scale,high quality and multi-center studies to be validated.%目的 利用Meta分析系统评价PTEN蛋白表达与中国人群前列腺癌发生的相关性. 方法 计算机检索PubMed、Embase、CBM、中国知网、维普和万方数据库,纳入有关PTEN蛋白表达与中国人群前列腺癌发生风险及不同临床病理特征相关性的病例-对照研究,采用Revman 5.3软件进行统计分析,并根据NOS量表进行偏倚风险评估. 结果 最终纳入26个研究,其中前列腺癌组1 025例,前列腺增生组461例,正常前列腺组37例.Meta分析结果显示:前列腺癌组织中PTEN蛋白的表达量低于前列腺增生患者[OR=0.03,95％CI(0.02,0.05),P＜0.01]和正常前列腺患者[OR=0.03,95 ％CI(0.01,0.11),P＜0.01],差异均有统计学意义.前列腺癌组织的中低分化组PTEN蛋白的表达量低于高分化组[OR=0.20,95 ％CI(0.15,0.27),P＜0.01];前列腺癌组织JWP分期中C+D期PTEN蛋白的表达量低于A+B期组[OR=0.11,95 ％CI(0.08,0.16),P＜0.01];前列腺癌患者中伴转移组PTEN蛋白的表达量低于未移组[OR=0.10,95％CI(0.05,0.19),P＜0.01],差异均有统计学意义. 结论 PTEN蛋白表达与中国人群前列腺癌发病风险及临床病理特征的相关性显著,鉴于受到纳入病例数量和文献质量的限制,上述结论亟待国内更多大样本、多中心、高质量研究来加以验证.
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