静脉用蔗糖铁注射液改善产科贫血的临床疗效观察

摘要

Objective To compare the efficacy and safety of intravenous iron sucrose and oral iron therapy for pregnancy with anemia,the new method was explored.Methods All of 40 patients with cervical cancer were randomly divided into experiment group (20 cases) and the control group (20 cases).The experiment group is received 200 mg intravenous iron sucrose plus 100 mL 0.9％ sodium chloride injection,while the control group is provided with compound ferrous sulfate and folic acid tablets,with 4 pills one time and 3 times a day for 4 weeks.The level of hemoglobin (Hb),hematokrit (Hct),serum ferritin (SF) and transferrin saturation (TSAT) of two groups were compared before and after therapy.Results The levels of Hb,Hct,SF and TSAT of patients significantly increased at 4 weeks after drug therapy (P ＜ 0.05),the levels of Hb,Hct,SF and TSAT of experiment group were significantly higher than those of control group (P ＜ 0.05).No adverse event was found in experiment group,while there were 3 cases with adverse gastrointestinal effects in control group.Conclusion Intravenous iron sucrose is effective and safe in improving iron deficiency anemia in pregnancy.%目的 比较静脉用蔗糖铁注射液与口服铁剂对产科贫血的疗效与安全性,研究改善产科贫血的新途径.方法 选取产科晚期妊娠中度贫血患者40例,随机分为实验组和对照组,各20例.实验组:每周2次静脉注射200 mg蔗糖铁注射液加0.9％氯化钠注射液100 mL,直至完成总补铁量；对照组:给予复方硫酸亚铁叶酸片口服,每日3次,每次4片,共4周.比较治疗前后患者的血红蛋白(Hb)、红细胞压积(Hct)、血清铁蛋白(SF)、血清转铁蛋白饱和度(TSAT).结果 用药4周后,两组患者Hb、Hct、SF、TSAT均较治疗前明显升高(P＜0.05)；治疗1、2、3、4周后,实验组Hb、Hct、SF、TSAT升高幅度明显优于对照组,差异有统计学意义(P＜0.05)；实验组在用药过程中无不良反应发生,对照组出现3例消化道不良反应.结论 静脉用蔗糖铁注射液对改善产科贫血有良好的临床疗效,且未见明显不良反应.